Evidence map›Paper›PMID 40172982›Full record

ArticleJournal of the American Society of Nephrology : JASN2025

Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability.

Lingzhi Liu, Lena L Rosenbaek, Mackenzie Kui, Samuel L Svendsen, Annemette Overgaard Brethvad, Alexander Jakobsen, Laura V Sparsoe, Aimi Hamilton, Mads V Sørensen, Mathias Skov and 9 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Novel Roles of GPCRs in the Renal Collecting Duct.Physiology (Bethesda, Md.) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization.American journal of physiology. Cell physiology · 2026
    Article
  6. Review
  7. Expanding Mechanistic Insights into Urinary Concentrating Ability.Journal of the American Society of Nephrology : JASN · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lingzhi LiuLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lena L RosenbaekDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-5143-3303
Mackenzie KuiDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7565-6413
Samuel L SvendsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-7446-054
Annemette Overgaard BrethvadLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Alexander JakobsenLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Laura V SparsoeDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Aimi HamiltonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3135-4106
Mads V SørensenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-6398-1035
Mathias SkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0009-0002-4711-4729
Jacob R TherkildsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-1048-7257
Jesper Kingo AndresenDepartment of Molecular Medicine, Cardiovascular and Renal Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.ORCID 0009-0006-7117-5408
Anna LaitakariSection of Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6558-660
Thomas M FrimurerSection of Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Boye Lagerbon JensenDepartment of Molecular Medicine, Cardiovascular and Renal Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-7607-213
Jennifer PluznickDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3621-2665
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-1623-199
Birgitte HolstLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7432-097
Helle PraetoriusDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.

Funding

Resource Development CoreU54DK137331 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DEIDRA CANDICE CREWS · 2023 to 2026
$4.3M
Olfactory Receptor 558 (OLFR558) Ligands and Blood Pressure RegulationR01DK137762 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Jennifer L Pluznick, Vladlen Z Slepak · 2024 to 2026
$2.0M
Sex Differences in Blood Pressure and Olfactory Receptor 558 (OLFR558)R01DK139021 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Jennifer L Pluznick · 2024 to 2026
$1.9M
Uncovering the Role of GPR39 in the kidneyF31DK137460 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KUI, MACKENZIE · 2024 to 2025
$89k
American Heart Association Established Investigator Award 949866NIDDK NIH HHS F31 DK137460NIDDK NIH HHS R01 DK137762NIDDK NIH HHS R01 DK139021NIDDK NIH HHS U54 DK137331NIH HHS R01DK139021, R01DK137762, and U54DK137331Office of Extramural Research, National Institutes of Health T32HL007534 and F31DK137460The Scandinavian Physiological Society NA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

epithelial sodium transportion transportkidney biology and physiologykidney tubulemetabolismrenal functionvasopressinwater channelswater-electrolyte balancewater transport

Identifiers

PMID40172982
PMCPMC12342097

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.