Evidence map›Paper›PMID 40175306›Full record

ArticleACS biomaterials science & engineering2025

Controlled-Release of Dexamethasone via Light-Activated Implant for Potential Vocal Fold Scar Treatment.

Avery Zheng, Nour Awad, Denzel Ryan D Cruz, Ruchika Pissay, Charles Farbos de Luzan, Gregory Dion, Yoonjee Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Avery ZhengDepartment of Chemical & Environmental Engineering, College of Engineering & Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45221, United States.ORCID 0009-0007-9875-4511
Nour AwadDepartment of Otolaryngology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, United States.ORCID 0009-0002-6900-2146
Denzel Ryan D CruzDepartment of Biomedical Engineering, College of Engineering & Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45221, United States.ORCID 0000-0002-1289-6962
Ruchika PissayDepartment of Biomedical Engineering, College of Engineering & Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Charles Farbos de LuzanDepartment of Otolaryngology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Gregory DionDepartment of Otolaryngology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Yoonjee ParkDepartment of Chemical & Environmental Engineering, College of Engineering & Applied Sciences, University of Cincinnati, Cincinnati, Ohio 45221, United States.ORCID 0000-0003-1454-0326

Funding

INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSISR21EB034840 · NIBIB · UNIVERSITY OF CINCINNATI · PI Gregory Robert Dion, Yoonjee Park · 2024 to 2026
$640k
Undergraduate Research for Dose-Controllable Drug Delivery ImplantsR15EY031500 · NEI · UNIVERSITY OF CINCINNATI · PI PARK, YOONJEE · 2021 to 2021
$475k
INJECTABLE, TUNABLE THERAPEUTIC IMPLANT TO REDUCE VOCAL FOLD SCARR21DC021038 · NIDCD · UNIVERSITY OF CINCINNATI · PI DION, GREGORY ROBERT, PARK, YOONJEE · 2023 to 2024
$442k
Co-Delivery Dose-Controllable Implants for Advanced Chronic Eye Disease TreatmentR03TR004429 · NCATS · UNIVERSITY OF CINCINNATI · PI PARK, YOONJEE · 2023 to 2024
$160k
NCATS NIH HHS R03 TR004429NEI NIH HHS R15 EY031500NIBIB NIH HHS R21 EB034840NIDCD NIH HHS R21 DC021038
6 · The paper itself

Abstract

This study investigates a novel light-activated implant system designed for injectable, dose-controlled, sustained drug delivery. The light-activated implant was developed by incorporating light-activated drug-releasing liposomes into a biodegradable polymeric capsule. The drug release kinetics from the implant at 0, 1, and 2 min of light activation were determined

Indexed as

CicatrixDexamethasoneVocal CordsAnimalsDelayed-Action PreparationsDrug Delivery SystemsDrug ImplantsDrug LiberationLightRabbitsSwineDelayed-Action PreparationsDexamethasonedexamethasone 21-phosphateDrug ImplantsControlled Long-Term Triggered Drug ReleaseDexamethasoneInjectable Biodegradable ImplantTheoretical Drug Release ModelVocal Fold Scarring

Identifiers

PMID40175306
PMCPMC12050067

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.