ArticleNature communications2025
Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Phthalate induced testicular degeneration in mice: biochemical, histopathological and immunohistochemical evidence for the interplay of oxidative stress, caspase-3, and NF-κB signaling.Scientific reports · 2026Article
- Deciphering the neurotoxic effects of emerging pollutants: Bisphenols and phthalates as disruptors of brain function and mental health.iScience · 2026Review
- Effects of Di(2-ethylhexyl) phthalate (DEHP) and hyperoxia on cardiovascular development in newborn rats.Pediatric research · 2026Article
- SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- Placental angiogenic biomarkers in relation to prenatal bisphenol and phthalate exposure.Placenta · 2026Article
- Evaluating Methods for High-Dimensional Mediation in Metabolomics Data.Environmental science & technology · 2026Article
- The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency.Environment international · 2025Article
- Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort.Science advances · 2025Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort.Environmental science & technology · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016-2018. We quantified eight phthalate metabolites in prenatal urine samples collected between 8- and 14-weeks' (visit 1; n = 216) and 24- and 30-weeks' gestation (visit 2; n = 145) and metabolite features in newborn dried-blood spot samples collected at delivery. Associations between phthalate metabolite concentrations and metabolic feature intensities at both visits were examined using adjusted generalized linear models (MWAS). Then, an exploratory meet-in-the-middle (MITM) analysis was conducted in a subset with NICU Neonatal Neurobehavioral Scale (NNNS) scores (visit 1 n = 81; visit 2 n = 71). In both the MWAS and MITM, many of the confirmed metabolites are involved in tyrosine and tryptophan metabolism, including tryptophan, tyrosine, thyroxine, and serine. This analysis elucidates how prenatal phthalate exposure disrupts the newborn metabolome and infant neurobehavioral outcomes.
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Registered trials
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