ArticleSchizophrenia (Heidelberg, Germany)2025
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.
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Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed.
- Functional brain connectivity in clinical high-risk youth from the Kenya psychosis-risk outcomes study (KePROS): functional network comparative area and topography analysis (FUNCATA).NeuroImage. Clinical · 2026Article
- Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations.Schizophrenia (Heidelberg, Germany) · 2025Article
- Pathways to prevention: the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Enabling FAIR data stewardship in complex international multi-site studies: Data Operations for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program.Schizophrenia bulletin open · 2025Article
- Neuroimaging in schizophrenia: From group-average abnormalities to individualised circuit models.Science progressReview
Corrections and comments
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Authors and funding
88 authors.
Michael P HarmsDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. mharms@wustl.edu.ORCID http://orcid.org/0000-0001-7945-036X
Kang-Ik K ChoDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7135-3848
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nicolas R BoloDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9941-622X
Sylvain BouixDepartment of Software Engineering and Information Technology, École de technologie supérieure, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-1326-6054
Dylan CampbellDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0008-5414-2801
Tyrone D CannonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Guillermo CecchiT.J. Watson Research Laboratory, IBM Research, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0003-1013-8348
Mathias GoncalvesDepartment of Psychology, Stanford University, Stanford, CA, USA.
Anastasia HaidarDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dylan E HughesDepartment of Psychology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0003-3759-2417
Igor IzyurovDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Omar JohnMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0008-3745-7270
Tina KapurDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nicholas KimDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elana KotlerMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marek KubickiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3989-8212
Joshua M KupermanDepartment of Radiology, University of California, San Diego, CA, USA.
Kristen LauletteDepartment of Psychology, University of California, Los Angeles, CA, USA.
Ulrich LindbergDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.ORCID http://orcid.org/0000-0002-0004-6354
Christopher MarkiewiczDepartment of Psychology, Stanford University, Stanford, CA, USA.
Lipeng NingDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Russell A PoldrackDepartment of Psychology, Stanford University, Stanford, CA, USA.
Yogesh RathiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paul A RomoSeaman Family MR Research Centre, Calgary, AB, Canada.
Zailyn TamayoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Cassandra WannanOrygen, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-1317-4635
Alana WickhamDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Walid YassinDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9612-0485
Juan Helen ZhouCentre for Sleep and Cognition and Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0180-8648
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-8298-0756
Luis AlamedaGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-8621-2885
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Nicholas J K BreitbordeDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6963-8884
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-5952-4605
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eric Yu Hai ChenDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-5247-3593
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network, Hartford, CT, USA.
Philippe ConusGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8902-4353
Barbara A CornblattDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, PA, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, King's College London, London, UK.
Pablo A GasparDepartment of Psychiatry, University of Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9682-5327
Carla GerberPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Louise Birkedal GlenthøjCopenhagen Research Centre for Mental Health, University of Copenhagen, Copenhagen, Denmark.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christy Lai Ming HuiDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Joseph KambeitzDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8988-3959
Lana Kambeitz-IlankovicDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.ORCID http://orcid.org/0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychosis Studies, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6825-6262
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-1060-1462
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6090-4974
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-9017-5119
Merete NordentoftCopenhagen Research Centre for Mental Health, University of Copenhagen, Copenhagen, Denmark.
Godfrey D PearlsonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Jesus PerezEarly Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9396-2206
Albert R PowersDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3057-5043
Jack RogersInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, CA, USA.
Jai L ShahDouglas Research Centre, McGill University, Montreal, Canada.ORCID http://orcid.org/0000-0002-7549-6990
Steven M SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0699-0960
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
William S StoneDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2932-7288
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, CA, USA.
Judy L ThompsonDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
Rachel UpthegroveDepartment of Psychology, Ohio State University, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0001-8204-5103
Swapna K VermaInstitute of Mental Health, Singapore, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5427-7425
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9731-8781
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5909-8004
John M KaneDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Patrick D McGorryOrygen, Parkville, Victoria, Australia.
Barnaby NelsonOrygen, Parkville, Victoria, Australia.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3103-5228
Martha E ShentonDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4235-7879
Stephen J WoodOrygen, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-4186-5919
Carrie E BeardenDepartment of Psychology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Funding
ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2MPsychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination CenterU24MH124629 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Rene S. Kahn, Martha E. Shenton · 2020 to 2026
$32.6MTrajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)U01MH124631 · NIMH · UNIVERSITY OF MELBOURNE · PI Christopher Barnaby Nelson · 2020 to 2026
$30.4MTraining Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8MNIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629NINDS NIH HHS T32 NS048004U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U24MH124629, U01MH124631, U01MH124639Wellcome TrustWellcome Trust (Wellcome) 220664/Z/20/Z, 220664/A/20/Z
Abstract
Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying prognostic or predictive biomarkers that can enhance our ability to forecast clinical outcomes. To date, most studies involving MRI in CHR are likely not sufficiently powered to generate robust and generalizable neuroimaging results. Here, we describe the prospective, advanced, and modern neuroimaging protocol that was implemented in a complex multi-site, multi-vendor environment, as part of the large-scale Accelerating Medicines Partnership® Schizophrenia Program (AMP® SCZ), including the rationale for various choices. This protocol includes T1- and T2-weighted structural scans, resting-state fMRI, and diffusion-weighted imaging collected at two time points, approximately 2 months apart. We also present preliminary variance component analyses of several measures, such as signal- and contrast-to-noise ratio (SNR/CNR) and spatial smoothness, to provide quantitative data on the relative percentages of participant, site, and platform (i.e., scanner model) variance. Site-related variance is generally small (typically <10%). For the SNR/CNR measures from the structural and fMRI scans, participant variance is the largest component (as desired; 40-76%). However, for SNR/CNR in the diffusion scans, there is substantial platform-related variance (>55%) due to differences in the diffusion imaging hardware capabilities of the different scanners. Also, spatial smoothness generally has a large platform-related variance due to inherent, difficult to control, differences between vendors in their acquisitions and reconstructions. These results illustrate some of the factors that will need to be considered in analyses of the AMP SCZ neuroimaging data, which will be the largest CHR cohort to date.Watch Dr. Harms discuss this article at https://vimeo.com/1059777228?share=copy#t=0 .
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