ArticleScientific reports2025
Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The vicious cycle of circadian disruption and obstructive sleep apnea: implications for cancer risk.Journal of the National Cancer Center · 2026Article
- Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules.Frontiers in medicine · 2026Review
- Molecular Biomarkers and Therapeutic Approach of Patients with Diabetes and Obstructive Sleep Apnea.International journal of molecular sciences · 2025Review
- Comparative effects of MAD and CPAP on heart rate in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Observational
- Melatonin and Cortisol Concentration Before and After CPAP Treatment of Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is associated with circadian rhythm dysregulation plausibly through affecting clock genes. The study's purpose was to investigate the effect of one-night continuous positive airway pressure treatment (CPAP treatment) on circadian clock genes: BMAL1, CLOCK, CRY1, and PER1 at mRNA and protein levels. The study included 30 OSA patients, who underwent diagnostic polysomnography (PSG) and next a one-night effective CPAP treatment with PSG monitoring (CPAP). The blood was collected in the evening before and the morning after PSG and CPAP. Protein levels and mRNA expression were measured using ELISA and qRT-PCR, respectively. The increase in PER1 expression was observed in the morning after compared to the evening before CPAP (p = 0.005); additionally, PER1 protein level decreased in the morning after CPAP compared to the morning after PSG (p = 0.035). In CLOCK protein levels significant changes were observed: an increase in the morning after CPAP compared to the morning after PSG (p = 0.049), an increase in the morning after CPAP compared to the evening before (p = 0.006), and an increase in difference between the morning after and evening before CPAP vs. difference between morning after and evening before PSG (p = 0.012). Obtained results suggest that even short-term effective CPAP treatment might reverse circadian clock signaling pathway disruption in OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.