Evidence map›Paper›PMID 40175501›Full record

ArticleScientific reports2025

Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer's disease.

Rezwanul Islam, Hadi Hasan Choudhary, Feng Zhang, Hritik Mehta, Jun Yoshida, Ajith J Thomas, Khalid Hanafy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Toll like receptor 4 (TLR4) in neuroinflammation: From acute hemorrhagic stroke to chronic neurodegeneration.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rezwanul IslamCooper Medical School of Rowan University, Camden, NJ, USA.
Hadi Hasan ChoudharyCooper Medical School of Rowan University, Camden, NJ, USA.
Feng ZhangCooper Medical School of Rowan University, Camden, NJ, USA.
Hritik MehtaCooper Medical School of Rowan University, Camden, NJ, USA.
Jun YoshidaCooper Medical School of Rowan University, Camden, NJ, USA.
Ajith J ThomasCooper Medical School of Rowan University, Camden, NJ, USA.
Khalid HanafyCooper Medical School of Rowan University, Camden, NJ, USA. hanafy@rowan.edu.

Funding

Modulation of the TLR4-Lyn interaction in SAHR01NS109174 · NINDS · ROWAN UNIVERSITY · PI HANAFY, KHALID A. · 2019 to 2023
$2.4M
NINDS NIH HHS R01 NS109174NINDS NIH HHS R01NS109174
6 · The paper itself

Abstract

Disease-Associated Microglia (DAM) are a focus in Alzheimer's disease (AD) research due to their central involvement in the response to amyloid-beta plaques. Microglial Toll-like receptor 4 (TLR4) is instrumental in the binding of fibrillary amyloid proteins, while Lyn kinase (Lyn) is a member of the Src family of non-receptor tyrosine kinases involved in immune signaling. Lyn is a novel, non-canonical, intracellular adaptor with diverse roles in cell-specific signaling which directly binds to TLR4 to modify its function. Lyn can be activated in response to TLR4 stimulation, leading to phosphorylation of various substrates and modulation of inflammatory and phagocytosis signaling pathways. Here, we investigated the TLR4-Lyn interaction in neuroinflammation using WT, 5XFAD, and 5XFAD x Lyn

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesMicrogliaNeuroinflammatory DiseasesNeuronsPhagocytosissrc-Family KinasesToll-Like Receptor 4AnimalsCell SurvivalDisease Models, AnimalHumansMiceMice, KnockoutMice, TransgenicSignal TransductionAmyloid beta-Peptideslyn protein-tyrosine kinasesrc-Family KinasesTlr4 protein, mouseToll-Like Receptor 45XFADAlzheimer’s diseaseDisease-Associated MicrogliaLyn kinaseTLR4TLR4-Lyn modulator protein

Identifiers

PMID40175501
PMCPMC11965285

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.