ArticleScientific reports2025
Encapsulation of L. fermentum with chitosan-alginate enhances its bioactivity against acrylamide toxicity in D.mel.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens.Frontiers in cellular and infection microbiology · 2026Review
- Encapsulated probiotics and nanoprobiotics - Biocompatible materials, processing technologies, and applications: A review.Biomolecules & biomedicine · 2025Review
- Probiotics as an Adjunct Ameliorates Ovarian Toxicity in Endotoxemic Mice via Modulating TLR 4/MyD88/NF-κB Signalling Pathway: Insights from In Vivo and In Silico Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Acrylamide (ACR), a neurotoxin typically present in thermally processed foods, is a substantial risk to people. The objective of this research is to develop synbiotic capsules with natural substances such as chitosan, alginate, and L. fermentum. Encapsulation is a significant tool in medicine, helping to improve targeted medication delivery and bioavailability. The chitosan/alginate-encapsulated probiotic (CAP) beads increase the bioavailability of probiotics in the gut, allowing for a more effective response to ACR-induced toxicity. The combination of prebiotic and probiotic activity improves stability, viability, and gastrointestinal delivery. We developed CAP beads and assessed their survivability under simulated gastrointestinal conditions, encapsulating efficiency, and release profile. The efficacy of these beads in reducing the harmful effects of ACR was subsequently investigated using a Drosophila melanogaster model. Under co-exposure and pre-treatment settings, in vivo studies revealed restoration of locomotor activities, redox balance, and ovarian mitochondrial membrane potential in flies treated with CAP beads. Furthermore, implying the indirect impact of CAP beads on gut microbiota and xenobiotic metabolism, pre-treatment with CAP more successfully restored the expression of important antioxidant and stress-related genes, including sod, cat, InR, rpr, and p53.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.