Evidence map›Paper›PMID 40175714›Full record

ReviewMolecular neurobiology2025

Exosomal MicroRNA: an Effective Strategy for the Treatment of Intracerebral Hemorrhage.

Yue Sun, Jiawei Liu, Wentao Sun, Baiwen Zhang, Yaxin Shang, Lei Zheng, Wei Zou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue SunHeilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Jiawei LiuHeilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Wentao SunFaculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning City, 530000, Guangxi, China.
Baiwen ZhangThe First Affiliated Hospital of Heilongjiang, University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Yaxin ShangHeilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Lei ZhengThe First Affiliated Hospital of Heilongjiang, University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Wei ZouThe First Affiliated Hospital of Heilongjiang, University of Chinese Medicine, Harbin, 150040, Heilongjiang, China. 18838128224@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage is a devastating type of stroke, and its pathological mechanism is very complex. Surgical treatment can effectively treat the primary injury caused by mechanical compression of hematoma after intracerebral hemorrhage. However, there is no effective treatment for the secondary injury caused by a series of pathological processes caused by extravasation of blood components, including inflammatory response, oxidative stress, and excitotoxicity. Therefore, there is an urgent need to develop a novel treatment regimen that can reverse the secondary damage of intracerebral hemorrhage. In recent years, as a powerful biomarker, the role of microRNAs (miRNAs) in diseases has been gradually disclosed. As nanocarriers, the miRNAs delivered by exosomes have become a new treatment method and are widely used in the treatment of various diseases. In this paper, the research progress on the mechanism of exosomal miRNAs in intracerebral hemorrhage and its value in prevention, diagnosis, and prognosis is summarized, hoping to provide some reference for the application of exosomal miRNAs in clinical treatment of intracerebral hemorrhage.

Indexed as

Cerebral HemorrhageExosomesMicroRNAsAnimalsHumansMicroRNAsExosomal miRNAExosomesIntracerebral hemorrhageMiRNANanocarrier

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.