Evidence map›Paper›PMID 40175829›Full record

ArticleCell biology and toxicology2025

Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury.

Joshua DeAguero, Tamara Howard, G Patricia Escobar, Karol Dokladny, Brent Wagner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gadolinium-Based Contrast Agents and the Theater of Safety.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua DeAgueroKidney Institute of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. joshdeaguero@salud.unm.edu.ORCID 0000-0001-6821-2067
Tamara HowardDepartment of Cell Biology & Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
G Patricia EscobarKidney Institute of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0002-4505-5297
Karol DokladnyKidney Institute of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0003-4912-9051
Brent WagnerKidney Institute of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. brwagner@salud.unm.edu.ORCID 0000-0002-7063-0142

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Joseph Endicott · 2017 to 2026
$24.9M
Chemokine Receptors in MRI Contrast-Induced Organ FibrosisR01DK102085 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WAGNER, BRENT · 2014 to 2017
$1.2M
BLRD VA I01 BX001958NCATS NIH HHS UL1 TR001449NCI NIH HHS P30 CA118100NIDDK NIH HHS R01 DK102085NIGMS NIH HHS P20 GM121176NIH HHS 3UL1TR001449-08S1NIH HHS DK-102085
6 · The paper itself

Abstract

The prevalence of contrast-enhanced magnetic resonance imaging (MRI) examinations and the absence of safer alternatives to gadolinium-based contrast agents (GBCAs) make the associated adverse effects of GBCAs much more concerning. Safety concerns arise from the toxic behavior of heavy metal gadolinium (Gd

Indexed as

Contrast MediaEndosomesEpithelial CellsGadoliniumKidney Tubules, ProximalLysosomesAnimalsCathepsin BCathepsin DCell LineCell SurvivalMiceCathepsin BCathepsin DContrast MediaGadoliniumCathepsinsGadolinium-based contrast agentsLysosomal damageMitochondrial dysfunctionMRI contrastRenal tubular cell injury

Identifiers

PMID40175829
PMCPMC11965215

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.