ArticleBMC neurology2025
Pyoderma gangrenosum in a patient with multiple sclerosis under natalizumab treatment: a case report.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Bilateral Idiopathic Pyoderma Gangrenosum: A Case Report of an Atypical Presentation.Clinical case reports · 2026Article
- JAK Inhibitors for Treatment of Pyoderma Gangrenosum and Sweet Syndrome: A Systematic Review of Published Case Reports.Dermatology research and practice · 2026Review
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5 authors.
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Abstract
backgroundPyoderma Gangrenosum (PG) is often considered an immune-mediated disease. Up to 50% of PG cases - a rare, non-infectious inflammatory skin disease characterized by painful necrotic ulcers -are associated with underlying systemic diseases like Rheumatoid Arthritis (RA), and Inflammatory Bowel Disease (IBD), moreover with monoclonal antibody therapy. CASE PRESENTATION: We described a 38-year-old female patient with multiple sclerosis (MS) who was treated for three years with Natalizumab. Myalgia, fever, and erythematous plaques accompanied by painful lesions in both upper extremities manifested with the fifteenth dosage of NTZ. After comprehensive testing and a Magnetic Resonance Imaging (MRI) scan, we excluded other systemic diseases and a recurrence of multiple sclerosis, respectively. After consulting a dermatologist, a skin biopsy was performed, and pathology report confirmed PG. Eventually, the lesions began to heal after stopping NTZ injection without receiving any dermatological care.
conclusionBased on PG incidence, it was associated with some medications like Rituximab and Ocrelizumab, on the other hand, after discontinuation of NTZ the lesions started to heal even without dermatological treatment. In our situation, it is conceivable that NTZ injection, and PG incidence are connected.
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