Evidence map›Paper›PMID 40176161›Full record

ArticleClinical epigenetics2025

Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study.

Ida Autio, Aino Saarinen, Saara Marttila, Emma Raitoharju, Pashupati P Mishra, Nina Mononen, Mika Kähönen, Liisa Keltikangas-Järvinen, Olli Raitakari, Terho Lehtimäki

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Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ida AutioDepartment of Psychology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
Aino SaarinenDepartment of Psychology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland. aino.i.saarinen@helsinki.fi.
Saara MarttilaMolecular Epidemiology, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.
Emma RaitoharjuMolecular Epidemiology, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.
Nina MononenDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University, Tampere, Finland.
Liisa Keltikangas-JärvinenDepartment of Psychology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.

Funding

Research Council of Finland 330809Research Council of Finland 349708
6 · The paper itself

Abstract

backgroundSleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epigenetic ageing is limited. We investigated (1) whether symptoms of insomnia, obstructive sleep apnoea, sleep deprivation, and circadian rhythm lateness are associated with epigenetic ageing, and (2) whether years spent in shift work moderates these associations.

methodsWe used the population-based Young Finns data (n = 1618). Epigenetic clocks such as AgeDev

resultsAmong the various sleep measures, obstructive sleep apnoea symptoms were most consistently linked to accelerated epigenetic ageing, as measured by AgeDev

conclusionsAmong various sleep measures, symptoms of obstructive sleep apnoea appear to be most consistently associated with accelerated epigenetic ageing even after adjusting for various health-related and socioeconomic factors. Shift work seems to have a crucial role in the relationship between sleep disturbances and epigenetic ageing in working-age adults.

Indexed as

AgingEpigenesis, GeneticShift Work ScheduleSleep Wake DisordersAdultDNA MethylationFemaleFinlandHumansMaleMiddle AgedSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSurveys and QuestionnairesYoung AdultBiological ageingChronotypeEpigenetic clockInsomniaObstructive sleep apnoeaShift workSleep quality

Identifiers

PMID40176161
PMCPMC11966881

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.