Evidence map›Paper›PMID 40176166›Full record

ArticleBiology of sex differences2025

Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring.

Snezana Milosavljevic, Maria V Piroli, Emma J Sandago, Gerardo G Piroli, Holland H Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Snezana MilosavljevicDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Maria V PiroliDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Emma J SandagoDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Gerardo G PiroliDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Holland H SmithDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Sarah BeggiatoDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Norma FrizzellDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA.
Ana PocivavsekDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26, 6311 Garners Ferry Rd, Columbia, SC, 29209, USA. ana.pocivavsek@uscmed.sc.edu.

Funding

The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHWARCZ, ROBERT · 2014 to 2023
$25.2M
Kynurenic Acid and Sleep: Focus on Maternal and Offspring HealthR01HL174802 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Ana Pocivavsek · 2024 to 2026
$2.0M
Investigating Citric Acid Cycle Perturbations in Complex I Deficient Mitochondrial EncephalopathyR01NS126851 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIZZELL, NORMA · 2022 to 2025
$1.5M
NHLBI NIH HHS R01 HL174802NIH HHS P50 MH103222NIMH NIH HHS P50 MH103222NINDS NIH HHS R01 NS126851
6 · The paper itself

Abstract

backgroundDisruptions in brain development can impact behavioral traits and increase the risk of neurodevelopmental conditions such as autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder, often in sex-specific ways. Dysregulation of the kynurenine pathway (KP) of tryptophan metabolism has been implicated in cognitive and neurodevelopmental disorders. Increased brain kynurenic acid (KYNA), a neuroactive metabolite implicated in cognition and sleep homeostasis, and variations in the Kmo gene, which encodes kynurenine 3-monooxygenase (KMO), have been identified in these patients. We hypothesize that parental Kmo genetics influence KP biochemistry, sleep behavior and brain energy demands, contributing to impairments in cognition and sleep in offspring through the influence of parental genotype and genetic nurture mechanisms.

methodsA mouse model of partial Kmo deficiency, Kmo heterozygous (HET-Kmo

resultsHET-Kmo

conclusionsThese findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo

Indexed as

Behavior, AnimalKynurenine 3-MonooxygenaseSex CharacteristicsAnimalsBrainCorticosteroneFemaleGenotypeKynurenic AcidKynurenineMaleMiceMice, Inbred C57BLSleepCorticosteroneKynurenic AcidKynurenineKynurenine 3-MonooxygenaseCognitionKynurenine pathwayNeurodevelopmentParental genotypeSleep

Identifiers

PMID40176166
PMCPMC11967062

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.