Evidence map›Paper›PMID 40176277›Full record

ArticleAmerican journal of industrial medicine2025

Gastroesophageal Reflux Disease in the World Trade Center Health Program General Responder Cohort.

Christopher R Dasaro, Ahmad Sabra, Henry S Sacks, Benjamin J Luft, Denise J Harrison, Iris G Udasin, Michael A Crane, Jacqueline M Moline, Winston Kwa, Andrew C Todd and 2 more

Abstract read
In one paragraph

Article in American journal of industrial medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher R DasaroDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ahmad SabraDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Henry S SacksDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin J LuftDepartment of Medicine, World Trade Center Health Program Clinical Center of Excellence, Stony Brook University Medical Center, Stony Brook, NY, USA.
Denise J HarrisonWorld Trade Center Health Program Clinical Center of Excellence, NYU Langone Medical Center, New York University School of Medicine, New York, NY, USA.
Iris G UdasinWorld Trade Center Health Program Clinical Center of Excellence, Environmental and Occupational Health Sciences Institute, Rutgers University Biomedical Sciences, Piscataway, NJ, USA.
Michael A CraneWorld Trade Center Health Program Clinical Center of Excellence, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jacqueline M MolineDepartment of Occupational Medicine, Epidemiology and Prevention, World Trade Center Health Program Clinical Center of Excellence, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Winston KwaDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew C ToddDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nancy L SloanDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3381-7602
Susan L TeitelbaumDepartment of Environmental Medicine, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

NIOSH CDC HHS HHSD200200200384CNIOSH CDC HHS HHSD200201139356CNIOSH CDC HHS HHSD200201139377CNIOSH CDC HHS HHSD200201793325CNIOSH CDC HHS U10 OH008216This work was supported by the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (cooperative agreements and contracts 200-2002-00384, U10-OH008216/23/25/32/39/75, 200-2011-39356/61/77/84/85/88, 200-2017-93325/28/29/30/31/32 and 75D30122C15187).
6 · The paper itself

Abstract

backgroundPeople participating in the rescue, recovery, and clean-up effort after the September 11, 2001 attack on the World Trade Center (WTC) were exposed to a complex mix of noxious substances and subsequently experienced elevated gastroesophageal reflux disease (GERD) incidence, the second-most-common WTC-related condition.

methodsLongitudinal WTC Health Program data, collected between July 2002 and December 2022, were used to describe the sample characteristics, diagnostic procedures, and treatment of consenting cohort members with self-reported GERD who reported incident GERD for a year or longer (n = 19,067). Cross-tabulations and binomial logistic regression, adjusted for confounders including comorbidities, assessed the associations with intermittent and resolved, compared with unresolved, GERD.

results12.6% of the study cohort reported intermittent GERD; 5.5% reported GERD resolution. Analyses indicated that most GERD resolution was reported by people of color and those with body mass index <25, and by cohort members who had longer postdiagnosis follow-up and implemented dietary modifications together with proton pump inhibitors or Program-approved antacids. GERD-certified members who underwent endoscopy, used medications without dietary modifications, or used bed head-elevation, and those with Barrett's disease (5.8%) or esophageal cancer (0.1%) may have had more severe GERD and reported little resolution.

conclusionsThe use of GERD services was consistent with clinical guidelines. Members' implementing dietary modifications in conjunction with proton pump inhibitors or Program-approved antacids reported more resolution and may have had less severe GERD. Earlier diagnosis and intervention might increase earlier therapeutic resolution.

Indexed as

Emergency RespondersGastroesophageal RefluxOccupational DiseasesOccupational ExposureSeptember 11 Terrorist AttacksAdultAgedFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedNew York CityProton Pump InhibitorsProton Pump Inhibitorsgastroesophageal reflux diseaseGERD treatmenthealth service utilizationrescue/recovery workWorld Trade Center

Identifiers

PMID40176277
PMCPMC12757917

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.