Evidence map›Paper›PMID 40177266›Full record

ArticleBioinformatics advances2025

RNApysoforms: fast rendering interactive visualization of RNA isoform structure and expression in Python.

Bernardo Aguzzoli Heberle, Madeline L Page, Emil K Gustavsson, Mina Ryten, Mark T W Ebbert

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bernardo Aguzzoli HeberleSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536-0298, United States.ORCID https://orcid.org/0000-0002-6177-9316
Madeline L PageSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536-0298, United States.
Emil K GustavssonDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom.ORCID https://orcid.org/0000-0003-0541-7537
Mina RytenDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom.
Mark T W EbbertSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536-0298, United States.ORCID https://orcid.org/0000-0001-9158-4440

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Using long-range technologies as a multi-omic approach to understand Alzheimer’s disease in brain tissueR01AG068331 · NIA · UNIVERSITY OF KENTUCKY · PI EBBERT, MARK T W · 2020 to 2024
$3.0M
Understanding how structural mutations and individual RNA isoformsare involved in human health and diseaseR35GM138636 · NIGMS · UNIVERSITY OF KENTUCKY · PI Mark T W Ebbert · 2020 to 2026
$2.9M
Genetic Architecture of Aging-Related TDP-43 and Mixed Pathology DementiaRF1AG082339 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM, NELSON, PETER T. · 2023 to 2023
$1.7M
NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG068331NIA NIH HHS RF1 AG082339NIGMS NIH HHS R35 GM138636
6 · The paper itself

Abstract

Summary: Alternative splicing generates multiple RNA isoforms from a single gene, enriching genetic diversity and impacting gene function. Effective visualization of these isoforms and their expression patterns is crucial but challenging due to limitations in existing tools. Traditional genome browsers lack programmability, while other tools offer limited customization, produce static plots, or cannot simultaneously display structures and expression levels. RNApysoforms was developed to address these gaps by providing a Python-based package that enables concurrent visualization of RNA isoform structures and expression data. Leveraging plotly and polars libraries, it offers an interactive, customizable, and faster-rendering framework suitable for web applications, enhancing the analysis and dissemination of RNA isoform research. Availability and implementation: RNApysoforms is a Python package available at (https://github.com/UK-SBCoA-EbbertLab/RNApysoforms) and (https://zenodo.org/records/14941190) via an open-source MIT license. It can be easily installed using the pip package installer for Python. Thorough documentation and usage vignettes are available at: https://rna-pysoforms.readthedocs.io/en/latest/.

Identifiers

PMID40177266
PMCPMC11964586

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.