Evidence map›Paper›PMID 40177765›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2024

Type 1 diabetes mellitus increases the risk of sudden sensorineural hearing loss: A two-sample Mendelian randomization study.

Yan Ding, Kangjia Zhang, Yong Zhang, Weijing Wu, Zi'an Xiao, Ruosha Lai

Abstract read
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In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yan DingDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011. 505483@csu.edu.cn.
Kangjia ZhangDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Yong ZhangDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Weijing WuDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Zi'an XiaoDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Ruosha LaiDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011. lairuosha@csu.edu.cn.

Funding

the Innovative Construction Foundation of Hunan Province China. 2023SK4030the Natural Science Foundation of Changsha kq2208326 and kq2208327
6 · The paper itself

Abstract

objectivesDiabetes mellitus is closely associated with sudden sensorineural hearing loss (SSNHL), but no definitive evidence has established a causal relationship between type 1 diabetes mellitus (T1DM) and SSNHL. This study aims to investigate the impact of T1DM on SSNHL from a genetic perspective, providing insights for risk prediction and treatment strategies.

methodsGenetic data related to exposure (T1DM) and outcome (SSNHL) were obtained from publicly available genome-wide association studies (GWAS). Instrumental variables were selected, and Mendelian randomization (MR) analysis was conducted to explore the causal association between T1DM and SSNHL. Inverse variance weighted (IVW) analysis was used as the primary method, with random-effects IVW serving as the main analytical approach. MR-Egger, weighted median, simple mode, and weighted mode analyses were utilized as supplementary methods. Cochran's

resultsA total of 127 SNPs were selected as instrumental variables for the MR analysis. IVW analysis demonstrated a genetically determined association between T1DM and SSNHL (

conclusionsTwo-sample MR analysis supports the conclusion that T1DM patients have an increased risk of developing SSNHL.

Indexed as

Diabetes Mellitus, Type 1Hearing Loss, SensorineuralHearing Loss, SuddenGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk Factorscausal relationshipMendelian randomizationrisksudden sensorineural hearing losstype 1 diabetes mellitus

Identifiers

PMID40177765
PMCPMC11964811

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.