Evidence map›Paper›PMID 40177768›Full record

SynthesisZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2024

Research progress in estrogen as an adjunctive therapy for schizophrenia.

Yanyu Ge, Shungeng Zhang, Xinbin Ge, Ranran Li, Jinguo Zhai, Yan Gao

Abstract readSystematic Review
In one paragraph

Synthesis in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [EstradiolZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanyu GeSchool of Mental Health, Jining Medical University, Jining Shandong 272067. 1161845783@qq.com.
Shungeng ZhangSchool of Clinical Medicine, Jining Medical University, Jining Shandong 272067.
Xinbin GeDepartment of General Surgery, Third Bethune Hospital of Jilin University, Changchun 130033.
Ranran LiDepartment of Psychiatry, Shandong Mental Health Center, Jinan 250014, China.
Jinguo ZhaiSchool of Mental Health, Jining Medical University, Jining Shandong 272067.
Yan GaoSchool of Mental Health, Jining Medical University, Jining Shandong 272067. gaoywl@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a chronic psychiatric disorder with complex etiology and diverse clinical manifestations, whose pathogenesis and triggering factors remain incompletely understood. Numerous studies have demonstrated significant gender differences in the age of onset, clinical presentation, disease progression, treatment efficacy, and prognosis among patients with schizophrenia. These differences are largely attributed to variations in sex hormone levels, with estrogen emerging as a key focus of research. Some studies suggest that adjunctive estrogen therapy during schizophrenia treatment not only alleviates symptoms but also reduces the required dosage of antipsychotic medications. A systematic review of research on estrogen as an adjunctive treatment for schizophrenia may provide new perspectives and references for future therapeutic strategies.

Indexed as

Antipsychotic AgentsEstrogensSchizophreniaClinical Trials as TopicEstrogen Replacement TherapyFemaleHumansMaleSex CharacteristicsAntipsychotic AgentsEstrogensadjunctive therapyestrogengender differencereproduction cycleschizophrenia

Identifiers

PMID40177768
PMCPMC11964812

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.