Evidence mapPaperPMID 40178097Full record

ArticleJournal of the American Heart Association2025

Amyloid β1-40 Predicts Long-Term Mortality Rate in Patients With Acute Myocardial Infarction.

Aneta Aleksova, Alessandra Lucia Fluca, Alessandro Pierri, Giulia Barbati, Antonio Paolo Beltrami, Laura Padoan, Enzo Merro, Maria Marketou, Donna Zwas, Stefano D'Errico and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aneta AleksovaCardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina Trieste Italy.ORCID 0000-0001-7711-9905
Alessandra Lucia FlucaCardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina Trieste Italy.ORCID 0000-0001-6427-8093
Alessandro PierriDepartment of Cardiology San Paolo Hospital Bari Italy.ORCID 0000-0003-0245-5220
Giulia BarbatiBiostatistics Unit, Department of Medical Surgical and Health Sciences University of Trieste Italy.
Antonio Paolo BeltramiDepartment of Medicine (DMED) Università degli Studi di Udine Udine Italy.ORCID 0000-0002-0679-2710
Laura PadoanCardiovascular Pathophysiology University of Perugia Italy.
Enzo MerroCardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina Trieste Italy.ORCID 0009-0002-0540-6969
Maria MarketouSchool of Medicine, Cardiology Department Heraklion University General Hospital, University of Crete Greece.ORCID 0000-0003-1888-3430
Donna ZwasLinda Joy Pollin Cardiovascular Wellness Center for Women Heart Institute, Hadassah University Medical Center Jerusalem Israel.ORCID 0000-0003-3025-3941
Stefano D'ErricoDepartment of Medical Surgical and Health Sciences University of Trieste Italy.ORCID 0000-0003-3689-0001
Gianfranco SinagraCardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina Trieste Italy.ORCID 0000-0003-2700-8478
Milijana JanjusevicCardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina Trieste Italy.ORCID 0000-0001-9579-1439

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyloid β1-40 (Aβ1-40) contributes to atherosclerosis, being involved in plaque formation and destabilization. The prognostic role of Aβ1-40 in patients with acute myocardial infarction is currently limited to non-ST-segment-elevation myocardial infarction (NSTEMI). We examined the prognostic value of Aβ1-40 in a real-world cohort of patients with acute myocardial infarction (both ST-segment-elevation myocardial infarction [STEMI] and NSTEMI) and identified predictors for its elevated levels. METHODS AND

resultsOur population included 1119 consecutive patients (mean age, 67 years; 72% men; and STEMI, 68%). The median Aβ1-40 concentration on admission was 86.9 (interquartile range, 54.5-128.9) pg/mL, and there was no difference in Aβ1-40 levels between NSTEMI and STEMI (

conclusionsAβ1-40 is an independent predictor of death and improves risk stratification in patients with acute myocardial infarction.

Indexed as

Amyloid beta-PeptidesNon-ST Elevated Myocardial InfarctionPeptide FragmentsST Elevation Myocardial InfarctionAgedBiomarkersFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsAmyloid beta-Peptidesamyloid beta-protein (1-40)BiomarkersPeptide Fragmentsacute myocardial infarctionamyloid β1‐40deathNSTEMIrisk stratificationSTEMI

Identifiers

PMID40178097
PMCPMC12132835

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.