Evidence map›Paper›PMID 40178592›Full record

ArticleArchives of toxicology2025

Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry.

Nicole E T Pinckaers, W Matthijs Blankesteijn, Anastasiya Mircheva, Ans Punt, Antoon Opperhuizen, Frederik-Jan van Schooten, Misha Vrolijk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicole E T PinckaersDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands. n.pinckaers@maastrichtuniversity.nl.ORCID 0009-0006-6879-5243
W Matthijs BlankesteijnDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.
Anastasiya MirchevaDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.
Ans PuntAns Punt Computational Toxicology, Arnhem, The Netherlands.
Antoon OpperhuizenDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.
Frederik-Jan van SchootenDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.
Misha VrolijkDepartment of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study predicts effective doses of a set of phenethylamine (PEA) analogues that are frequently present in pre-workout and weight-loss food supplements, to prioritize these compounds for further risk assessment. In vitro determined EC

Indexed as

Dietary SupplementsModels, BiologicalPhenethylaminesReceptors, AdrenergicReceptors, G-Protein-CoupledDose-Response Relationship, DrugHumansRisk AssessmentTrace Amine-Associated ReceptorsphenethylaminePhenethylaminesReceptors, AdrenergicReceptors, G-Protein-CoupledTrace Amine-Associated ReceptorsAdrenergic receptorsPBK modellingPhenethylamine analoguesQIVIVETrace amine-associated receptor 1

Identifiers

PMID40178592
PMCPMC12085399

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.