Evidence map›Paper›PMID 40178665›Full record

ArticleNatural products and bioprospecting2025

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1.

Wei-Ye Wu, Xun Wei, Qiong Liao, Yi-Fan Fu, Lei-Ming Wu, Lei Li, Shu-Qi Wu, Qing-Ren Lu, Fang-Yu Yuan, Dong Huang and 3 more

Abstract read
In one paragraph

Article in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei-Ye Wu *School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Xun Wei *School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Qiong LiaoLaboratory Animal Center, Sun Yat-sen University, Guangzhou, 510006, China.
Yi-Fan FuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Lei-Ming WuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Lei LiSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Shu-Qi WuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Qing-Ren LuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Fang-Yu YuanSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Dong HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhang-Hua SunGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan, 512005, China.
Tao YuanThe Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China.
Gui-Hua TangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. tanggh5@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-8831-7154

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021B1515140062National Natural Science Foundation of China 22407144National Natural Science Foundation of China 82404454Science and Technology Planning Project of Guangdong Province 2023A1111120025Science and Technology Program of Guangzhou, China 2024B03J1322
6 · The paper itself

Abstract

A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC

Indexed as

AlkaloidsCytotoxic activityEndophytic fungusPenicillium canescensPolyketides

Identifiers

PMID40178665
PMCPMC11968604

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.