Evidence map›Paper›PMID 40178669›Full record

ArticleMolecular and cellular biochemistry2025

GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway.

Jianli Wang, Ting Geng, Xiaomei Yao, Yiming Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianli WangDepartment of Neurology, Qilu Hospital of Shandong University, No.107 Wenhua West Road, Lixia District, Jinan, 250012, Shandong, China.
Ting GengDepartment of Oncology, Zibo Maternal and Child Health Hospital, Zibo, 255020, Shandong, China.
Xiaomei YaoDepartment of Geriatrics, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250102, Shandong, China.
Yiming LiuDepartment of Neurology, Qilu Hospital of Shandong University, No.107 Wenhua West Road, Lixia District, Jinan, 250012, Shandong, China. liuym@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth differentiation Factor 15 (GDF15) plays an important role in the innate immune response. However, whether GDF15 could regulate Parkinson's disease (PD) remains unknown. In this study, we explored the function and underlying molecular mechanisms of GDF15 in PD. The protein and mRNA expressions were examined applying immunofluorescence staining, Western blot and qRT-PCR. Ferrous iron content was also assessed using an iron assay kit. The effect of GDF15 knockdown on mitochondrial membrane potential, ROS level, intracellular Fe

Indexed as

Growth Differentiation Factor 15Membrane ProteinsNucleotidyltransferasesParkinson DiseaseSignal TransductionAnimalsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease ProgressionHumansMaleMiceMice, Inbred C57BLSTING ProteincGAS protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGDF15 protein, humanGdf15 protein, mouseGrowth Differentiation Factor 15Membrane ProteinsNucleotidyltransferasesSTING1 protein, humanSting1 protein, mouseSTING ProteincGAS-STING pathwayFerroptosisGDF15InflammationParkinson's disease

Identifiers

PMID40178669

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.