ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Reproducibility of Plasma Metabolome over 1 Year in a Population-Based Cohort of Black Breast Cancer Survivors.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Residential green space, air pollution, and related metabolites in association with depression among cancer survivors.Nature communications · 2026Article
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11 authors.
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Abstract
backgroundThe metabolomics approach using blood samples from epidemiologic studies has the potential to elucidate pathways or uncover biomarkers for breast cancer outcomes. Therefore, understanding the within-person reproducibility of the blood metabolome and the factors that influence metabolite levels over time in breast cancer survivors are crucial, but these remain largely unknown.
methodsWe estimated the within-person reproducibility of plasma metabolites in 61 Black breast cancer survivors from the Women's Circle of Health Follow-Up Study. Samples were collected from each participant at two time points, approximately 2 and 3 years after diagnosis. Untargeted metabolomic profiles were analyzed by Metabolon using ultrahigh-performance LC/MS-MS. We calculated the intraclass correlation coefficients (ICC) for each metabolite by dividing the between-person variance by the total variance. ICCs were compared across preanalytic factors (e.g., fasting) and participant characteristics using the Wilcoxon test.
resultsAmong 857 named metabolites, the median ICC was 0.58 (IQR: 0.44-0.70). Of the metabolites, 16.6% showed high within-person reproducibility (ICC ≥ 0.75), spanning all metabolite classes, whereas 65.6% had an ICC within 0.4 to 0.75, and 17.9% had an ICC < 0.4. Reasonable ICCs were also observed for nonfasting samples (median 0.53, IQR: 0.39-0.67), although lower than those for fasting samples (median 0.63, IQR: 0.45-0.77). ICCs were slightly lower in younger, nonobese participants and in women with estrogen receptor-positive breast cancer.
conclusionsThe within-person reproducibility of plasma metabolites over 1 year among breast cancer survivors was generally acceptable. IMPACT: A single-timepoint measurement could be useful in evaluating associations between metabolites and breast cancer outcomes.
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