ArticlePloS one2025
TENS improves CFL injury rat and regulates the intestinal microbiota.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Transcutaneous electrical nerve stimulation improves lateral ankle sprain (LAS) in rats by regulating the CXCL10/NF-kB signaling pathway: a potential treatment for LAS.Molecular biology reports · 2026Article
- Transcutaneous electrical nerve stimulation changed the relative abundance of intestinal microbiota in rats with knee osteoarthritis: a potential treatment for KOA.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Anti-inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota.Animal models and experimental medicine · 2026Article
- Effects of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory on the skeletal muscle repair and gut microbiota modulation in rats with gastrocnemius muscle injury.Frontiers in rehabilitation sciences · 2026Article
- The role of biotics and bioactive compounds in sports injuries: a narrative review.Frontiers in nutrition · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study revealed the mechanism of transcutaneous electrical nerve stimulation (TENS) for improving the calcaneofibular ligament (CFL) injury rats by regulating the intestinal microbiota.
methodsAfter 1, 2, and 3 weeks of TENS treatment, the improvement of CFL injury rats model and the expressions of IL-1β/NF-κB/IL-17 signaling pathway were measured. Then the intestinal microbiota was analyzed by 16S rDNA sequencing and its functions related to improve CFL injury rat were analyzed.
resultsTENS could improved the athletic ability of CFL injury rats and reduced the expressions of IL-1β/NF-κB by regulating the IL-17 signaling pathway. By 16S rDNA sequencing analysis, the TENS treatment improved the intestinal dysbacteriosisof CFL injury rats and decrease pathogenic bacteria Ruminococcus and Dubosiella. The changed intestinal microbiota maybe relative with the ankle injury, whereas the increase in probiotics (Bacteroides and Lactobacillus) was relative with anti-inflammation.
conclusionTENS could down-regulate the expressions of IL-1β/NF-κB to improve CFL injury rat. TENS could change the intestinal microbiota of CFL rats and the changed bacteria whose function related to anti-inflammation could improve CFL rat. The intestinal microbiota could become a potential treatment for CFL injury.
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