Evidence map›Paper›PMID 40180244›Full record

ReviewJournal of advanced research2026

Comprehensive insights into emerging advances in the Neurobiology of anorexia.

Liwei Mao, Lian Wang, Zhihai Huang, Jian-Kang Chen, Lorelei Tucker, Quanguang Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liwei MaoDepartment of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Lian WangDepartment of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Zhihai HuangDepartment of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.
Jian-Kang ChenDepartments of Cellular Biology & Anatomy and Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Lorelei TuckerDepartment of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Quanguang ZhangDepartment of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA. Electronic address: qzhang@augusta.edu.

Funding

Tubular Hypertrophy and AKI Susceptibility in DiabetesR01DK143226 · AUGUSTA UNIVERSITY · 2025 to 2025
$596k
NIDDK NIH HHS R01 DK083575NIDDK NIH HHS R01 DK114328NIDDK NIH HHS R01 DK143226
6 · The paper itself

Abstract

backgroundAnorexia is a complex eating disorder influenced by genetic, environmental, psychological, and socio-cultural factors. Research into its molecular mechanisms and neural circuits has deepened our understanding of its pathogenesis. Recent advances in neuroscience, molecular biology, and genetics have revealed key molecular and neural circuit mechanisms underlying anorexia. AIM OF REVIEW: Clarify the peripheral and central molecular mechanisms regulating various types of anorexia, identify key cytokines and neural circuits, and propose new strategies for its treatment. Key scientific concepts of review: Anorexia animal models, including activity-induced, genetic mutation, and inflammation-induced types, are explored for their relevance to studying the disorder. Anorexic behavior is regulated by cytokines, hormones (like GDF15, GLP-1, and leptin), and neural circuits such as AgRP, serotonergic, dopaminergic, and glutamatergic pathways. Disruptions in these pathways, including GABAergic signaling in AgRP neurons and 5-HT2C and D2 receptors, contribute to anorexia. Potential therapies target neurotransmitter receptors, ghrelin receptors, and the GDF15-GFRAL pathway, offering insights for treating anorexia, immune responses, and obesity.

Indexed as

AnorexiaNeurobiologyAnimalsCytokinesDisease Models, AnimalGrowth Differentiation Factor 15HumansSignal TransductionCytokinesGrowth Differentiation Factor 155-HTActivity-based anorexiaAgRPAnorexia nervosaCancer cachexiaGDF15Neural projections

Identifiers

PMID40180244
PMCPMC12766255

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.