Statins × adverse events & safety

TrialThe lancet. HIV2025

Statin effects on the incidence of major non-cardiovascular disease events among a global cohort of people with HIV: a randomised controlled trial.

Marissa R Diggs et al.PubMed ↗Full text ↗Publisher ↗

  • Pitavastatin 4 mg dailyno clear effectNo clear effect on major non-CVD events.Nothing cleared the noise.

What the trial testedas reported · 7,769 people · 2025

Range includes no effect

No clear effect on major non-CVD events

−8%−24% to +13%

pitavastatin 4 mg daily vs placebo

Bigger than 3 in 10 for adverse events & safety

As reported

HR 0.92, 95% CI 0.76–1.13

Who was studied, and how

7,769people with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

pitavastatin 4 mg daily
placebo

No clear effect on major non-CVD events−8%

randomised

the abstract, start to end

(hazard ratio [HR], cause-specific: 0.92, 95% CI 0.76-1.13; p=0.44).

← favours treatmentfavours comparator →
could be chance
Major non-CVD events (including AIDS-defining events, non-AIDS-defining cancers, renal disease, and liver disease)pitavastatin 4 mg daily vs placebo
HR 0.920.76–1.13
StatinsAdverse events & safety

Statins × adverse events & safetyharms?mixed

unlikelylikely
0.160.20 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 6

1 paper cites it

2025
2026
this papertrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 40180472