ArticleJACC. Asia2025
Sex Differences in Outcomes After Contemporary Percutaneous Coronary Intervention: Insights From the PENDULUM Registry.
Article in JACC. Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Sex differences in long-term outcomes by platelet reactivity in patients with chronic kidney disease.Heart and vessels · 2026Article
- Risk and all-cause mortality of high low-density lipoprotein cholesterol-albumin ratio level in stable coronary artery disease patients following percutaneous coronary intervention.Frontiers in endocrinology · 2026Article
- Sex differences in mortality after percutaneous coronary intervention: a contemporary nationwide registry and prospective cohort analysis.Annals of translational medicine · 2025Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex differences in clinical outcomes remain controversial in patients treated with a drug-eluting stent (DES).
objectivesThe purpose of this study was to investigate whether the effects of sex differences on ischemic and bleeding outcomes vary by bleeding risk in patients undergoing contemporary percutaneous coronary intervention (PCI) with a second-generation DES and predominant use of potent P2Y
methodsThe PENDULUM (Platelet rEactivity in patieNts with DrUg eLUting stent and balancing risk of bleeding and ischeMic event) registry was a prospective, multicenter, PCI registry in Japan. The primary endpoints were major adverse cardiac and cerebrovascular events (MACCE) and major bleeding (Bleeding Academic Research Consortium types 3 and 5) 30 months after the index PCI.
resultsOf the 6,266 patients included in this subgroup analysis, 1,357 patients (21.7%) were women. The incidences of MACCE and major bleeding at 30 months were similar between the sexes (MACCE: 9.4% vs 9.4%, HR: 1.00 [95% CI: 0.82-1.22]; P = 1.000; major bleeding: 4.2% vs 4.5%, HR: 1.07 [95% CI: 0.81-1.43]; P = 0.628). After adjustment, female sex was associated with lower incidences of MACCE at 30 months (adjusted HR: 0.65 [95% CI: 0.51-0.82]; P < 0.001). There was no interaction between sex and high bleeding risk for MACCE and major bleeding at 30-month follow-up (P for interaction = 0.926 and 0.617, respectively).
conclusionsFemale sex is an independent predictor of lower ischemic outcomes but not bleeding outcomes at 30 months in patients undergoing contemporary PCI with a second-generation DES and predominant use of potent P2Y
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