Evidence map›Paper›PMID 40181095›Full record

ArticleEMBO reports2025

Reciprocal rescue of Wolfram syndrome by two causative genes.

Su Jin Ham, Eunju Yoon, Da Hyun Lee, Sehyeon Kim, Heesuk Yoo, Jongkyeong Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Su Jin Ham *Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.ORCID 0000-0001-5230-3386
Eunju Yoon *Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.ORCID 0000-0003-3009-8144
Da Hyun Lee *Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.ORCID 0000-0003-0985-9092
Sehyeon KimInstitute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.ORCID 0000-0002-5737-210X
Heesuk YooInstitute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.ORCID 0000-0002-0624-1118
Jongkyeong ChungInstitute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea. jkc@snu.ac.kr.ORCID 0000-0001-5894-7537

Funding

Ministry of Education, Korea BK21 Plus ProgramNational Research Foundation of Korea (NRF) RS-2020-NR049538National Research Foundation of Korea (NRF) RS-2023-00211029National Research Foundation of Korea (NRF) RS-2024-00339984
6 · The paper itself

Abstract

Wolfram syndrome (WS) is marked by juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. The causative genes, WFS1 and CISD2, correspond to WS types 1 and 2, respectively. Here, we establish their mutual indispensability for inositol 1,4,5-triphosphate receptor (IP

Indexed as

Drosophila ProteinsIron-Sulfur ProteinsMembrane ProteinsMitochondrial ProteinsWolfram SyndromeAmino Acid SequenceAnimalsCalciumCell LineDrosophila melanogasterEndoplasmic ReticulumFemaleHumansInositol 1,4,5-Trisphosphate ReceptorsMaleProtein BindingCalciumCisd2 protein, DrosophilaDrosophila ProteinsInositol 1,4,5-Trisphosphate ReceptorsIron-Sulfur ProteinsMembrane ProteinsMitochondrial Proteinswolframin proteinCalciumCISD2IP3RWFS1Wolfram Syndrome

Identifiers

PMID40181095
PMCPMC12069674

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.