ArticleCommunications biology2025
Paclobutrazol induces triterpenoid biosynthesis via downregulation of the negative transcriptional regulator SlMYB in Sanghuangporus lonicericola.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- The transcription factorHorticulture research · 2026Article
- Squalene inPlants (Basel, Switzerland) · 2026Article
- Assessment of the effect of paclobutrazol treatment on the activity of genes related to flavonoid synthesis in Brassica napus under salt stress conditions.BMC plant biology · 2026Article
- Fungal-fungal interaction between Sanghuangporus vaninii and its endophytic Fusarium solani rewires host secondary metabolism to boost bioactive metabolite production.Microbial cell factories · 2026Article
- Integrated transcriptomic and targeted triterpenoid profiling reveals key enzymes in triterpenoid biosynthesis of Oplopanax elatus.Scientific reports · 2026Article
- Comparative Untargeted Metabolomic Analysis of Fruiting Bodies from ThreeJournal of fungi (Basel, Switzerland) · 2025Article
- From Logs to Bags: A Metabolic Blueprint of Sanghuang Cultivation Revealed by UPLC-Q-TOF-MS/MS and Amino Acid Profiling.Molecules (Basel, Switzerland) · 2025Article
- Intercropping withFrontiers in microbiology · 2025Article
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Authors and funding
12 authors.
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Abstract
Triterpenoids are well-known pharmacological components of Sanghuangporus fungi, such as Sanghuangporus lonicericola. This study investigates the inductive effects of paclobutrazol (PBZ) on triterpenoid biosynthesis in the submerged fermentation of S. lonicericola and explores the induction mechanisms via multi-omics and genetic methods. The addition of 100 mg/L PBZ significantly increases the triterpenoid yield by 151.39%. A total of 29 triterpenoids are tentatively identified, of which 18 are newly presented only under PBZ induction. Moreover, 30 genes involved in the MVA pathway and 31 genes encoding cytochrome P450 monooxygenases assumed to be responsible for decoration are identified. Finally, a MYB transcription factor (SlMYB) is identified and found to be downregulated under paclobutrazol induction. Genetic manipulation of SlMYB demonstrates its negative regulatory effect on four putative target genes, including ACAT, MVD, IDI, and FDPS. Electrophoretic mobility gel shift assays verify the direct interactions with the promoters of MVD, IDI, and FDPS. Taken together, PBZ acts as an effective inducer of triterpenoid biosynthesis in S. lonicericola, and the transcription factor SlMYB is negatively regulated.
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