Observational studyBMC psychiatry2025
Effects of childhood trauma on depression and cognitive function in first-diagnosed, drug-naïve depressed patients: an observational case-control study.
Observational study in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis.Psychological medicine · 2026Article
- Joint developmental trajectories of anxious/depressive symptoms and aggressive behavior in Chinese adolescents: The roles of contextual, personality, and cognitive factors.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundChildhood trauma is associated with development of depression, yet a comprehensive investigation into the relationship between childhood trauma and depression severity, as well as cognitive impairment and omega-3 polyunsaturated fatty acids (n-3 PUFAs) levels remains to be fully explored.
methodsA total of 97 patients undergoing first-diagnosed, drug-naïve depression and 60 healthy controls (HCs) were recruited in this study. The evaluation included the Childhood Trauma Questionnaire (CTQ), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), Beck depression inventory (BDI), Self-rating anxiety scale (SAS), Repeatable battery for the assessment of neuropsychological status (RBANS) scores and n-3 PUFAs levels.
resultsEmotional abuse (p < 0.000), sexual abuse (p = 0.002) and CTQ total scores (p = 0.001) were significantly higher in first-diagnosed, drug-naïve depressed patients compared to healthy controls. Additionally, depressed patients with a history of childhood trauma exhibited higher scores on HAMA (p = 0.043), SAS (p = 0.009) and BDI (p = 0.032), along with lower eicosapentaenoic acid (EPA) levels (p = 0.025). Subsequent analysis revealed positive correlations between CTQ total score and HAMA (p = 0.0389), SAS (p = 0.0112), HAMD (p = 0.0398) and BDI scores (p = 0.0323), and negative correlations with EPA level (p = -0.2843) and delayed memory (p = 0.0444), as determined by Pearson correlation analysis.
conclusionsWe report for the first time that first-diagnosed drug-naïve patients experienced more severe childhood trauma than healthy controls. Furthermore, depressed individuals with a history of childhood trauma exhibited more pronounced clinical characteristics of depression and lower level of EPA. Notably, childhood trauma was associated with depression severity, delayed memory impairment and lower EPA levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.