Evidence map›Paper›PMID 40182148›Full record

ArticleFrontiers in neuroscience2025

Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs.

Ekaterina Levichkina, David B Grayden, Steven Petrou, Mark J Cook, Trichur R Vidyasagar

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In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ekaterina LevichkinaDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia.
David B GraydenDepartment of Biomedical Engineering, The University of Melbourne, Parkville, VIC, Australia.
Steven PetrouFlorey Institute of Neuroscience & Mental Health, University of Melbourne, Parkville, VIC, Australia.
Mark J CookDepartment of Biomedical Engineering, The University of Melbourne, Parkville, VIC, Australia.
Trichur R VidyasagarDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of a seizure relies on two factors. One is the existence of an overexcitable neuronal network and the other is a trigger that switches normal activity of that network into a paroxysmal state. While mechanisms of local overexcitation have been the focus of many studies, the process of triggering remains poorly understood. We suggest that, apart from the known exteroceptive sources of reflex epilepsy such as visual, auditory or olfactory signals, there is a range of interoceptive triggers, which are relevant for seizure development in Temporal Lobe Epilepsy (TLE). The hypothesis proposed here aims to explain the prevalence of epileptic activity in sleep and in drowsiness states and to provide a detailed mechanism of seizures triggered by interoceptive signals.

Indexed as

circadian rhythmepilepsyHippocampusipRGC (intrinsically photosensitive retinal ganglion cells)sleepvagus

Identifiers

PMID40182148
PMCPMC11965934

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.