Evidence map›Paper›PMID 40182844›Full record

ReviewFrontiers in medicine2025

The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer.

Nikola Odehnalová, Viera Šandriková, Róbert Hromadka, Markéta Skaličková, Petr Dytrych, David Hoskovec, Zdeněk Kejík, Jan Hajduch, Frédéric Vellieux, Martina Koziar Vašáková and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. How Emerging Nanomaterials are Effective in Bone Regeneration?International journal of nanomedicine · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nikola OdehnalováNEXARS Research and Development Center C2P s.r.o, Chlumec nad Cidlinou, Czechia.
Viera ŠandrikováNEXARS Research and Development Center C2P s.r.o, Chlumec nad Cidlinou, Czechia.
Róbert HromadkaNEXARS Research and Development Center C2P s.r.o, Chlumec nad Cidlinou, Czechia.
Markéta SkaličkováBIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.
Petr DytrychDepartment of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
David HoskovecDepartment of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
Zdeněk KejíkBIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.
Jan HajduchBIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.
Frédéric VellieuxBIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.
Martina Koziar VašákováDepartment of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czechia.
Pavel MartásekDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
Milan JakubekBIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer and neurodegenerative diseases, and they also display high usability in regenerative medicine. Emphasizing their diagnostic potential, exosomes serve as carriers of disease-specific biomarkers, enabling non-invasive early detection and personalized medicine. The cargo loading of exosomes with therapeutic agents presents an innovative strategy for targeted drug delivery, minimizing off-target effects and optimizing therapeutic interventions. In regenerative medicine, exosomes play a crucial role in intercellular communication, facilitating tissue regeneration through the transmission of bioactive molecules. While acknowledging existing challenges in standardization and scalability, ongoing research efforts aim to refine methodologies and address regulatory considerations. In summary, this review underscores the transformative potential of exosomes in reshaping the landscape of medical interventions, with a particular emphasis on cancer, neurodegenerative diseases, and regenerative medicine.

Indexed as

biomarkercancerexosomesneurodegenerative diseasesregenerative medicine

Identifiers

PMID40182844
PMCPMC11966052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.