Evidence map›Paper›PMID 40183050›Full record

ReviewPeerJ2025

The relationship between MAPK signaling pathways and osteogenic differentiation of periodontal ligament stem cells: a literature review.

Xuanning Liu, Wanqing Zhao, Yanhui Peng, Na Liu, Qing Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuanning Liu *Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China.
Wanqing Zhao *Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China.
Yanhui PengHebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China.
Na LiuDepartment of Preventive Dentistry, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China.
Qing LiuHebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a common oral disease that can lead to gingival inflammation, development of periodontal pockets, resorption of the alveolar bone, and the loosening and eventual loss of teeth. The optimal outcome of periodontitis treatment is maximum regeneration and functional reconstruction of periodontal tissues after control of infection and elimination of inflammation. Since both the self-healing ability of alveolar bone and the efficacy of traditional treatment methods are very limited, stem cell-based tissue regeneration engineering has received more and more attention from scholars. The best cells for periodontal tissue regeneration have been well examined, and these are called periodontal ligament stem cells (PDLSCs). The MAPK signaling pathways, including the ERK1/2, p38 MAPK, JNK, and ERK5 signaling pathways, are very complex and highly conserved tertiary kinase signaling pathways. These pathways are closely related to the osteogenic differentiation of PDLSCs, and this paper provides an overview of the research on the MAPK signaling pathways and the osteogenic differentiation of PDLSCs.

Indexed as

Cell DifferentiationMAP Kinase Signaling SystemOsteogenesisPeriodontal LigamentStem CellsAnimalsHumansPeriodontitisMAPK signaling pathwaysOsteogenic differentiationPeriodontal ligament stem cells

Identifiers

PMID40183050
PMCPMC11967421

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.