Evidence map›Paper›PMID 40183841›Full record

ArticleNeurochemical research2025

Targeting UAF1 Alleviate Neurotoxicity by Inhibiting APP/NLRP3 Axis-Mediated Pyroptosis and Apoptosis.

Ling Cheng, Xianguang Meng, Dandan Tian, Bin Zheng, Yinfan Xiao, Xueying Zhao, Yingying Xu, Hui Yang, Jianzhong Bi, Fan Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ling ChengDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Xianguang MengDepartment of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China.
Dandan TianDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Bin ZhengDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Yinfan XiaoDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Xueying ZhaoDepartment of Blood Transfusion, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Yingying XuDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Hui YangDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Jianzhong BiDepartment of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.
Fan Li *Department of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China. 201162013888@email.sdu.edu.cn.
Zhaohong Xie *Department of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China. xie_zhaohong@sdu.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2023MH340Shandong University Multidisciplinary Research and Innovation Team of Young Scholars 2020QNQT019the Fundamental Research Funds of Chinese Academy of Medical Sciences 2019-RC-HL-026the National Natural Science Foundation of China 81870848
6 · The paper itself

Abstract

The accumulation of amyloid β (Aβ) protein, derived from the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of Alzheimer's disease (AD) by inducing neuronal cell injury. This study investigated the specific functions of ubiquitin-specific protease 1-associated factor 1 (UAF1) in mediating the neurotoxic effects triggered on Aβ. To model AD-related neuronal injury in vitro and in vitro, SH-SY5Y cells exposed to Aβ

Indexed as

Amyloid beta-Protein PrecursorApoptosisNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCell Line, TumorHippocampusHumansMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsPeptide FragmentsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePeptide FragmentsAlzheimer’s disease (AD)ApoptosisAβNLRP3PyroptosisUAF1

Identifiers

PMID40183841
PMCPMC11971201

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.