ArticleJournal of endocrinological investigation2025
The spectrum of hypophosphatemia in internal medicine: lessons from a Greek population study.
Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypophosphatemia, a common but often overlooked electrolyte disorder in hospitalized patients, lacks routine monitoring. This study aimed to assess the incidence, causes and associated biochemical and clinical features, as well as concurrent electrolyte and acid-base disturbances and mortality in patients with hypophosphatemia in an internal medicine ward.
methodsWe prospectively included adult patients who either presented with or developed hypophosphatemia (serum phosphate levels < 2.5 mg/dL or 0.81 mmol/L) during hospitalization.
resultsAmong 4,095 patients, 4.3% (n = 176) had or developed hypophosphatemia. Of those, 126 patients (71.6%) had hypophosphatemia on admission, while 50 patients (28.4%) developed hypophosphatemia during hospitalization. All but one patient exhibited mild (72.2%) or moderate (27.3%) hypophosphatemia with serum phosphate levels between 2 and 2.5 mg/dL (0.65-0.81 mmol/L) and 1-2 mg/dL (0.32-0.65 mmol/L), respectively. The most common potential causes of phosphate depletion were respiratory alkalosis, malnutrition, drugs, e.g. diuretics and corticosteroids, diabetes mellitus and secondary hyperparathyroidism, with most patients (75.6%) exhibiting more than one likely causes. 64.8% of patients had at least one concomitant electrolyte disorder, the most common being hypocalcemia (40.9%), hyponatremia (38.6%), hypomagnesemia (23.9%) and hypokalemia (22.7%). 77% of patients exhibited pure or mixed acid-base disorders, mainly respiratory alkalosis (48.3%). Mortality was markedly higher in hypophosphatemic patients compared to the overall hospitalized population (15.9% vs. 4.26%). Furthermore, 8.1% of discharged patients had died within a month. Patients who developed hypophosphatemia during hospitalization were older, with higher incidence of hyponatremia and mortality rate (16% versus 5.6%). They also had higher parathyroid hormone and lower vitamin D levels, compared with those with hypophosphatemia on admission.
conclusionsHypophosphatemia in internal medicine patients is often multifactorial and may signal greater illness severity. The high prevalence of associated electrolyte and acid-base disturbances suggests shared underlying mechanisms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.