ArticleProbiotics and antimicrobial proteins2026
Antioxidant and Immunostimulatory Effects of Lactobacillus Strains in RAW 264.7 Macrophages via NF-κB and MAPK Signaling Pathways.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Immune-Enhancing Effects of IBP35, a Combination ofFood science & nutrition · 2026Article
- ProbioticJournal of microbiology and biotechnology · 2026Article
- Lactose-Free Fermented Milk Production UsingJournal of microbiology and biotechnology · 2026Article
- Link between physical activity, nutrition, and antimicrobial pharmacokinetics and therapeutic efficacy: Implications for resistance management.SAGE open medicine · 2026Review
- Comparative inhibition of oral pathogens, biofilm formation, and inflammation-related responses by postbiotics fromJournal of oral microbiology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern stressors such as stress, irregular lifestyles, lack of exercise, and poor eating habits weaken immunity, thereby increasing susceptibility to infections and chronic diseases. Probiotics are functional ingredients that regulate gut microbiota, enhance immune function, and reduce oxidative stress. In this study, we identified novel probiotic candidates with antioxidant and immunostimulatory properties. Lactiplantibacillus plantarum WB4304, L. plantarum WB4305, and Levilactobacillus brevis WB4306, isolated from the traditional fermented food kimchi, exhibited acid and bile salt tolerance and strong adhesion to HT-29 cells, suggesting their suitability for intestinal colonization. Their safety was confirmed through hemolytic activity, bile salt hydrolase activity, and antibiotic susceptibility assays. Notably, L. plantarum WB4304 and L. plantarum WB4305 exhibited higher radical scavenging activities than Lacticaseibacillus rhamnosus GG. These strains significantly enhanced nitric oxide (NO) production and phagocytosis in RAW 264.7 macrophages. Immune activation was mediated by upregulation of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α through the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Among the three strains, L. plantarum WB4304 and L. plantarum WB4305 exhibited the most pronounced immunostimulatory effects. These findings suggest the potential of L. plantarum WB4304, L. plantarum WB4305, and L. brevis WB4306 as safe and functional probiotics, with promising applications in oxidative stress management and immune health enhancement.
Indexed as
Identifiers
40184022What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.