Observational studyMedicine2025
MicroRNA-204 may predict the renal function in patients with chronic kidney disease.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Long Non-Coding RNAs and Micro RNAs in Chronic Kidney Disease: Recent Advances and Future Directions-A 5-Year Systematic Review.Life (Basel, Switzerland) · 2026Review
- miRNA in the Progression of Diabetic Kidney Disease: New Insight.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease significantly affects human health by loss of excretory kidney function. MicroRNAs have potential predictive and therapeutic significance for chronic kidney disease and fibrosis-related kidney diseases. This study aimed to investigate expression profiling and clinical significance of microRNA-204 (miR-204) expression in patients with chronic kidney disease.
methodsA total of 126 patients with chronic kidney disease and age-matched 126 healthy controls were enrolled in this study. Blood samples were collected from participants and expression levels of miR-204 were detected using reverse transcription quantitative polymerase chain reaction. Expression of inflammatory cytokines in glomerular cells was measured using reverse transcription quantitative polymerase chain reaction. Inflammatory cytokines in serum were analyzed using enzyme-linked immunosorbent assay in all participants. Multivariate Cox-regression analysis was used to analyze the association between serum level of miR-204 and inflammation, renal fibrosis, and degree of chronic kidney disease.
resultsChronic kidney disease patients had higher inflammatory cytokines including IL-1β, IL-6, TNF-α, IL-10, and IL-17 than healthy volunteers. Expression levels of inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-10, and IL-17) were upregulated in patients with chronic kidney disease compared to healthy volunteers. Serum level of miR-204 was lower in chronic kidney disease patients than healthy patients. Expression of miR-204 was higher in healthy volunteers than patients with chronic kidney disease. In addition, expression of miR-204 was lower in glomerular cells in chronic kidney disease patients than those in the healthy volunteers. Furthermore, higher serum level of miR-204 was associated with better renal function in chronic kidney disease patients than patients who had lower serum level of miR-204. High serum levels of miR-204 were associated with degree of renal fibrosis and injury of chronic kidney disease patients. Multivariate Cox-regression analysis identified expression of miR-204 was positively correlated with inflammation in patients with chronic kidney disease.
conclusionOutcomes indicate that serum levels of miR-204 are downregulated in serum in patients with chronic kidney disease. Data suggest that serum levels of miR-204 can be used to evaluate the renal function in patients with chronic kidney disease.
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