ArticleExperimental & molecular medicine2025
Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression.
Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of biological sciences · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Transmembrane 4 L six family member 5 (TM4SF5) is involved in hepatocellular carcinoma (HCC) development and progression. Although TM4SF5 also promotes migration and invasion, it remains unclear how the metabolic context affects metastatic potential. Here we explored how TM4SF5 affects albumin uptake for HCC progression using TM4SF5 knockout or reintroduced hepatocyte and animal systems. Serum-deprived hepatocytes formed filopodia-like processes depending on TM4SF5 expression, which was altered by albumin replenishment for membranous PIP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.