ArticleBMC cardiovascular disorders2025
Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A randomized controlled trial on the application of a chronic disease management platform based on digital health technology combined with an innovative model of intelligent management for hypertension in patients with hypertension.Frontiers in digital health · 2025Trial
- Article
- Non-traditional lipid-inflammatory parameters estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study.Journal of advanced research · 2026Article
- Association Between Serum Creatinine to Cystatin C Ratio and Activities of Daily Living Disability Trajectories: Evidence From the China Health and Retirement Longitudinal Study.Geriatrics & gerontology international · 2026Article
- Enhanced Qualities of High-Density Lipoproteins (HDLs) with Antioxidant Abilities Are Associated with Lower Susceptibility of Hypertension in Middle-Aged Korean Participants: Impaired HDL Quality and Hypertension Risk.International journal of molecular sciences · 2026Article
- Predictive Value of Triglyceride/HDL-C Ratio for Unplanned Coronary Revascularization in Elderly Patients With Type 2 Diabetes and Coronary Artery Disease: A Retrospective Cohort Study.Aging medicine (Milton (N.S.W)) · 2025Article
- Relationship of the metabolic score for insulin resistance and the new-onset hypertension: Evidence from CHARLS.PloS one · 2025Article
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5 authors.
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Abstract
backgroundThe triacylglycerol to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been recognized as one of the risk factors for cardiovascular diseases, insulin resistance and metabolic syndrome. We aimed to investigate the relationship between TG/HDL-C and hypertension in a Chinese middle-aged and elderly population.
methodsWe used data from the CHARLS database 2011-2018 to explore the relationship between TG/HDL-C and hypertension through cross-sectional and longitudinal studies. Hypertension was identified by self-report or taking anti-hypertensive medications. Participants aged below 45, or with missing data on TG/HDL-C or hypertension record, or taking lipid-lowering medication were excluded. Participants were divided into three or two groups based on triplets TG/HDL-C and median TG/HDL-C in cross-sectional and longitudinal analysis. Multivariate logistic regression analysis, subgroup analysis, and restricted cubic splines were used in statistics.
resultsIn the cross-sectional analysis, a total of 12,824 participants were included, after adjusting for potential confounders, there was a significant association between higher TG/HDL-C and increased prevalence of hypertension (OR = 1.86, 95% CI: 1.65-2.09, p < 0.001), systolic blood pressure (SBP) above 140 mmHg (OR = 1.37, 95% CI: 1.25-1.50, p < 0.0001), diastolic blood pressure (DBP) above 90 mmHg (OR = 1.47, 95% CI: 1.29-1.67, p < 0.0001), and pulse pressure (PP) above 60 mmHg (OR = 1.17, 95% CI: 1.07-1.29, p < 0.0011). The longitudinal analysis included 7909 participants, there was a significant association between higher TG/HDL-C and increased incidence of hypertension (OR = 1.51, 95% CI: 1.32-1.73,p < 0.001). Restricted cubic splines show nonlinear relationship between TG/HDL-C and hypertension.
conclusionThese results demonstrated significant positive association between TG/HDL-C and the prevalence & incidence of hypertension, in a nationwide representative middle-aged and elderly population in China.
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