Evidence map›Paper›PMID 40186346›Full record

ArticleClinical and translational allergy2025

What is the influence of exacerbations on pulmonary function in pediatric and adolescent patients with severe asthma despite controller therapies?

A Z P Brandão, L M L B F Lasmar, L M A S Pertence, M I R Vieira, G B Lasmar, V O Ganem, E V Mancuzo, M V N P de Queiroz

Abstract read
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In one paragraph

Article in Clinical and translational allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Z P BrandãoDepartment of Pediatric Pulmonology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
L M L B F LasmarDepartment of Pediatric Pulmonology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0009-0003-5991-1837
L M A S PertenceDepartment of Pediatric Pulmonology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
M I R VieiraDepartment of Pediatric Pulmonology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
G B LasmarMultidisciplinary Center for Difficult-to-Control Asthma, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
V O GanemMultidisciplinary Center for Difficult-to-Control Asthma, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
E V MancuzoPulmonary Function Laboratory, Department of Internal Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
M V N P de QueirozDepartment of Pediatric Pulmonology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough exacerbations are common in severe asthma, there have been few longitudinal studies evaluating their effect on lung function parameters. This study aimed to evaluate the impact of exacerbations on lung function in children and adolescents with severe asthma in Brazil.

methodsThis was a prospective study in which lung function parameters-forced vital capacity (forced vital capacity [FVC]), forced expiratory volume in 1 s (forced expiratory volume in 1 s [FEV1]), the FEV

resultsThe mean duration of prior use of an inhaled corticosteroid together with a long-acting bronchodilator or other controller was 6.7 (SD 3.2) years. During the study period, 31 patients (48.5%) had exacerbations. We analyzed 479 pulmonary function tests and found no significant association between exacerbation and any of the lung function parameters: FEV

conclusionsIn children and adolescents with severe asthma who are using preventive treatment, exacerbations do not seem to be associated with impaired lung function.

Indexed as

adolescentasthmachildexacerbationrespiratory function testsspirometry

Identifiers

PMID40186346
PMCPMC11971237

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.