Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: a randomized controlled trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05256888 (Time-Restricted Eating to Address Persistent Cancer-Related Fatigue), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time-Restricted Eating to Address Persistent Cancer-Related Fatigue: The Fatigue REDuction After Cancer (FREDA) Trial
Who cites it
3 citing papers in PubMed.
- Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.Chronobiology international · 2026Article
- Fasting-Based Dietary Interventions in Cancer Patients and Survivors: A Scoping Review.Nutrients · 2026Article
- Article
Corrections and comments
- Update of
Authors and funding
11 authors.
Funding
Abstract
purposeTime-restricted eating (TRE) helps regulate rest-activity rhythms, blood glucose, and other diurnally regulated energetics processes, which may have implications for persistent fatigue. In a randomized controlled trial, we tested the effects of TRE vs. control on fatigue in cancer survivorship.
methodsAdult cancer survivors were recruited who were 2 months to 2 years post-treatment and reported moderate to severe fatigue. Participants were randomized 1:1, TRE:control, and all received individualized nutrition counseling. The TRE group self-selected a 10-h eating window for 12 weeks. At baseline, week 6, and week 12, participants were asked to log eating instances, complete the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire (FACIT-F, higher score = less fatigue), and wear an actigraph and continuous glucose monitor.
resultsThirty participants completed baseline assessments and were randomized (77% female, 53% Black/African American, 43% White, 7% Hispanic; 54.1 ± 14.7 years old; 87% with blood cancer); 25 completed 12-week assessments. TRE led to a meaningful reduction in fatigue at week 12 controlling for baseline levels (change in FACIT-F fatigue subscale = 0.0 ± 5.4 for control, 4.1 ± 5.7 for TRE, p = 0.11, effect size (ES) = 0.70; clinically meaningful threshold = 3.0 points). Glucose parameters (e.g., average interstitial glucose, average fasting glucose) tended to be lower, and rest-activity rhythms tended to indicate more regularity for those in the TRE vs. control group at weeks 6 and 12, though differences were not statistically significant (p > 0.19).
conclusionsA 12-week, nutritionist-led TRE program led to less fatigue than control. Continued study of TRE patterns are warranted to optimize this eating pattern and address persistent cancer-related fatigue.
trial registrationClinicalTrials.gov Identifier: NCT05256888.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.