ArticleCell reports. Medicine2025
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer.
Abstract read
In one paragraph
Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Beyond Feature Selection: Interpretable Machine Learning for Mechanistic Insights in Metabolomics.Biology · 2026Review
- Artificial intelligence models: transforming early diagnosis and precise treatment of gastrointestinal cancers.Molecular cancer · 2026Review
- Comparative spatial whole transcriptome analysis of matched frozen and formalin-fixed paraffin-embedded colorectal cancer tissues.Biochemistry and biophysics reports · 2026Article
- Liquid biopsy, multi-cancer early detection, and artificial intelligence: new frontiers in cancer screening from a technological and immunological perspective.Frontiers in immunology · 2026Review
- From biomarkers to mechanisms: deepening the clinical translation of inflammatory indices in colorectal cancer pathogenesis.International journal of surgery (London, England) · 2026Article
- Exploiting artificial intelligence in precision oncology: an updated comprehensive review.Journal of translational medicine · 2025Review
- Drug resistance in cancer: molecular mechanisms and emerging treatment strategies.Molecular biomedicine · 2025Review
- Gut Microbiota and Ferroptosis in Colorectal Cancer: A Comprehensive Review of Mechanisms and Therapeutic Strategies to Overcome Immune Checkpoint Resistance.Biomolecules · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors.
Shumei ChiaGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore. Electronic address: chiasm1@gis.a-star.edu.sg.
Justine Jia Wen SeowGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Rafael Peres da SilvaGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Chayaporn SuphavilaiGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Niranjan ShirgaonkarGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Maki Murata-HoriGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Xiaoqian ZhangGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Elena Yaqing YongGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Jiajia PanNational Cancer Centre, Singapore, Singapore.
Matan Thangavelu ThangaveluGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore.
Giridharan PeriyasamyGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore.
Aixin YapGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Padmaja AnandGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Daniel MuliaditanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Yun Shen ChanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China.
Wang SiyuGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Chua Wei YongGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Nguyen HongGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Gao RanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Ngak Leng SimGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Yu Amanda GuoGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Andrea Xin Yi TehNational Cancer Centre, Singapore, Singapore.
Clarinda Chua Wei LingNational Cancer Centre, Singapore, Singapore.
Emile Kwong Wei TanDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Fu Wan Pei CherylinDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Meihuan ChangDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Shuting HanNational Cancer Centre, Singapore, Singapore.
Isaac Seow-EnDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Lionel Raphael Chen HuiDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Anna Hwee Hsia GanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Choon Kong YapGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Huck Hui NgGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Anders Jacobsen SkanderupGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Vitoon ChinswangwatanakulDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Cancer Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Woramin RiansuwanDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Atthaphorn TrakarnsangaDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Manop PithukpakornSiriraj Genomics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol, Bangkok, Thailand.
Pariyada TanjakDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Cancer Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Amphun ChaiboonchoeSiriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Daye ParkDivision of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Dong Keon KimDivision of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Narayanan Gopalakrishna IyerNational Cancer Centre, Singapore, Singapore.
Petros TsantoulisHôpitaux Universitaires de Genève, University of Geneva, Geneva, Switzerland.
Sabine TejparDepartment of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.
Jung Eun KimR&D center PODO Therapeutics Co. 338 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13493, Republic of Korea.
Tae Il KimR&D center PODO Therapeutics Co. 338 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13493, Republic of Korea; Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Somponnat SampattavanichSiriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Iain Beehuat TanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; National Cancer Centre, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore. Electronic address: iaintan@duke-nus.edu.sg.
Niranjan NagarajanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: nagarajann@gis.a-star.edu.sg.
Ramanuj DasGuptaGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; CRUK Scotland Institute, School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: ramanuj.dasgupta@glasgow.ac.uk.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, which applies ML on next-generation pharmacogenomic datasets generated from a freeze-viable biobank of patient-derived primary cell lines (PDCs). These PDCs are screened against 84 Food and Drug Administration (FDA)-approved drugs at clinically relevant doses (C
Indexed as
Biomarkers, TumorColorectal NeoplasmsPrecision MedicineCell Line, TumorDrug Resistance, NeoplasmFluorouracilHumansMachine LearningMultiomicsPhenotypePrognosisTreatment OutcomeBiomarkers, TumorFluorouracil5-FU resistancebiomarkerchromosome 7 amplificationcolorectal cancerdrug screenhead and neck cancermachine learningpatient-derived cancer modelsPDCpharmacogenomicsprecision oncology
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.