Evidence map›Paper›PMID 40187358›Full record

ArticleCell reports. Medicine2025

Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients.

Mengyun Hu, Ana Paula B N Oliveira, Zhuoqing Fang, Yupeng Feng, Molly Miranda, Sangeeta Kowli, Prabhu S Arunachalam, Gowri Vasudevan, Harold Sai-Yin Hui, Alba Grifoni and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mengyun HuInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Ana Paula B N OliveiraDepartment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Zhuoqing FangInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Yupeng FengInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Molly MirandaInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Sangeeta KowliInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Prabhu S ArunachalamInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA.
Gowri VasudevanDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Harold Sai-Yin HuiInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Alba GrifoniCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Matthew LitvackHope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA, USA.
Nadine RouphaelHope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA, USA.
Mehul S SutharDepartment of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA, USA.
Xuhuai JiInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Holden T MaeckerInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Thomas HaganDepartment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gundeep DhillonDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Mark R NicollsDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Bali PulendranInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: bpulend@stanford.edu.

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
Endothelial Injury, BMPR2 Dysfunction and Macrophage Activation Cause EndMT and PAHR01HL138473 · NHLBI · STANFORD UNIVERSITY · PI Mark Robert Nicolls, Marlene Rabinovitch · 2017 to 2026
$4.9M
Vaccination responses in lung transplant recipientsU01HL163124 · NHLBI · STANFORD UNIVERSITY · PI Gundeep Singh Dhillon, Mark Robert Nicolls · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL138473NHLBI NIH HHS U01 HL163124NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI167903
6 · The paper itself

Abstract

The effectiveness of COVID-19 mRNA vaccines is diminished in organ transplant patients. Using a multi-omics approach, we investigate the immunological state of lung transplant (LTX) recipients at baseline and after SARS-CoV-2 mRNA vaccination compared to healthy controls (HCs). LTX patients exhibit a baseline immune profile resembling severe COVID-19 and sepsis, characterized by elevated pro-inflammatory cytokines (e.g., EN-RAGE [also known as S100A12], interleukin [IL]-6), reduced human leukocyte antigen (HLA)-DR expression on monocytes and dendritic cells, impaired cytokine production, and increased plasma microbial products. Single-cell RNA sequencing identifies an enriched monocyte cluster in LTX patients marked by high S100A family expression and reduced cytokine and antigen presentation genes. Post vaccination, LTX patients show diminished antibody, B cell, and T cell responses, along with blunted innate immune signatures. Integrative analysis links these altered baseline immunological features to impaired vaccine responses. These findings provide critical insights into the immunosuppressed condition of LTX recipients and their reduced vaccine-induced adaptive and innate immune responses.

Indexed as

COVID-19COVID-19 VaccinesLung TransplantationSARS-CoV-2AdultAgedB-LymphocytesCytokinesDendritic CellsFemaleHLA-DR AntigensHumansImmunity, InnateMaleMiddle AgedMonocytesCOVID-19 VaccinesCytokinesHLA-DR Antigensendotoxin tolerancehuman immunologyimmunocompromisedlung transplantmonocytesmulti-omicssepsissystems immunologysystems vaccinologyvaccines

Identifiers

PMID40187358
PMCPMC12047491

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.