ReviewNature communications2025
The Estonian Biobank's journey from biobanking to personalized medicine.
Abstract readReview
In one paragraph
Review in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.Nature human behaviour · 2026Pooled it
- Pooled it
- Loneliness and Personality: Noise- and Bias-Free True Correlations Between Loneliness and the Big Five Personality Domains.Journal of personality · 2026Article
- From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.Nature communications · 2026Review
- Delivery mode and maternal health conditions before and after childbirth: A population-based cohort study from Estonia.Acta obstetricia et gynecologica Scandinavica · 2026Article
- An AI-Health infrastructure for the Nordic region: technical foundations, data assets, and a roadmap for deployment.Nature medicine · 2026Article
- Article
- Article
- The case for an integrated biobanking initiative in South Asia.The Lancet regional health. Southeast Asia · 2026Review
- From evidence to implementation: key priorities for pharmacogenomics-guided treatment and prevention from a European expert workshop.European journal of human genetics : EJHG · 2026Article
- Prescribed hormonal contraceptive use trends in the Estonian Biobank: A longitudinal observational study.PLoS medicine · 2026Observational
- Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Nature genetics · 2026Article
- An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles.Nature communications · 2026Article
- Fifteen Years of the Genome Analysis Toolkit as the De Facto Standard in Short-Read Variant Calling.International journal of molecular sciences · 2026Review
- Article
- Circadian rhythms regulate refractive development across species.bioRxiv : the preprint server for biology · 2026Article
- Unraveling genotype-phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis.BMC genomics · 2026Article
- Insights and priorities from the 2025 private funders' Parkinson's disease and related disorders large footprint data interoperability summit.Journal of Parkinson's disease · 2026Article
- Interpreting artificial neural networks to detect genome-wide association signals for complex traits.NAR genomics and bioinformatics · 2026Article
- Pharmacokinetic recall study of Estonian Biobank participants with novel genetic variants in CYP2C19 and CYP2D6.NPJ genomic medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. lili.milani@ut.ee.ORCID http://orcid.org/0000-0002-5323-3102
Maris AlverEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Sven LaurInstitute of Computer Science, University of Tartu, Tartu, Estonia.
Sulev ReisbergInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-6835-9632
Toomas HallerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Oliver AasmetsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Erik AbnerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-6529-3161
Helene AlavereEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.
Annely AllikEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.
Tarmo AnniloEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Krista FischerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3521-0599
Robin HofmeisterEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-9965-595X
Georgi HudjashovEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Maarja JõelooEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mart KalsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-2090-8780
Liis Karo-AstoverEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Silva KaselaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Anastassia KoldeEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0009-0002-6963-7053
Kristi KrebsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-0494-2751
Kertu Liis KrigulEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Jaanika KronbergEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-2362-656X
Karoliina KruusmaaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Viktorija KukuškinaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kadri KõivEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-5286-2014
Kelli LehtoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Liis LeitsaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Sirje LindEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.
Laura Birgit LuitvaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kristi LällEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kreete LüllEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-9722-5876
Kristjan MetsaluEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mait MetspaluEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-3099-9161
René MõttusInstitute of Psychology, University of Tartu, Tartu, Estonia.
Mari NelisEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Tiit NikopensiusEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Miriam NurmEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-7156-8216
Margit NõukasEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Marek OjaInstitute of Computer Science, University of Tartu, Tartu, Estonia.
Elin OrgEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-8688-9717
Marili PaloverEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Priit PaltaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-9320-7008
Vasili PankratovCentre for Genomics, Evolution and Medicine, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-7928-4402
Kateryna PantiukhEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Natalia PervjakovaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Natàlia Pujol-GualdoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Anu ReigoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0009-0008-0226-3396
Ene ReimannEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5410-4433
Steven SmitEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3791-635X
Diana RogozinaEstonian Biobank, Institute of Genomics, University of Tartu, Tartu, Estonia.
Dage SärgEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-9077-1604
Nele TabaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1953-2819
Harry-Anton TalvikInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-1423-1497
Maris Teder-LavingEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5872-1850
Neeme TõnissonEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mariliis VahtEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Uku VainikEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Urmo VõsaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-3476-1652
Burak YelmenEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-0731-0223
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Raivo KoldeInstitute of Computer Science, University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2964-6011
Jaak ViloInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-5604-4107
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1501-9030
Andres MetspaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. andres.metspalu@ut.ee.ORCID http://orcid.org/0000-0002-3718-796X
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large biobanks have set a new standard for research and innovation in human genomics and implementation of personalized medicine. The Estonian Biobank was founded a quarter of a century ago, and its biological specimens, clinical, health, omics, and lifestyle data have been included in over 800 publications to date. What makes the biobank unique internationally is its translational focus, with active efforts to conduct clinical studies based on genetic findings, and to explore the effects of return of results on participants. In this review, we provide an overview of the Estonian Biobank, highlight its strengths for studying the effects of genetic variation and quantitative phenotypes on health-related traits, development of methods and frameworks for bringing genomics into the clinic, and its role as a driving force for implementing personalized medicine on a national level and beyond.
Indexed as
Biological Specimen BanksPrecision MedicineEstoniaGenomicsHumans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.