Evidence map›Paper›PMID 40188291›Full record

Trial reportBritish journal of cancer2025

PD-L1 imaging with [

Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Ronan Tegala, Damion Bailey, Kathryn Adamson, Scott Edmonds, Levente K Meszaros, Amelia Elizabeth Broomfield Moore, Thubeena Manickavasagar and 11 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04436406 (Measurement of PD-L1 Expression in Cancer to Monitor Treatment Response.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436406 naunknown statusnot on this map

Measurement of PD-L1 Expression in Cancer to Monitor Treatment Response.

TypeinterventionalSponsorGuy's and St Thomas' NHS Foundation TrustRan2020 to 2024Enrolled30ConditionsNon-small Cell Lung Cancer, MelanomaArms[99mTc]-NM-01 SPECT/CT
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Daniel Johnathan HughesDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK.ORCID http://orcid.org/0000-0003-2641-7632
Gitasha ChandDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK.
Jessica JohnsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Ronan TegalaDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Damion BaileyDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Kathryn AdamsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Scott EdmondsDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Levente K MeszarosNanomab Technology (UK) Limited, Borehamwood, Hertfordshire, UK.
Amelia Elizabeth Broomfield MooreDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK.
Thubeena ManickavasagarDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK.
Susan NdagireKing's Health Partners Cancer Biobank, Cancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.
Spyridon GennatasCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Alexandros GeorgiouCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0001-7500-9251
Sharmistha GhoshCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Debra JosephsCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5610-9123
Eleni KarapanagiotouCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Emma McLeanDepartment of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Hong Hoi TingNanomab Technology (UK) Limited, Borehamwood, Hertfordshire, UK.
James SpicerCancer Centre at Guy's, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-3732-8491
Vicky GohDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK.ORCID http://orcid.org/0000-0002-2321-8091
Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 5th Floor Becket House, London, UK. gary.cook@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8732-8134

Funding

Cancer Research UK (CRUK) C1519/A28682Wellcome TrustWellcome Trust (Wellcome) WT 203148/Z/16/Z
6 · The paper itself

Abstract

backgroundProgrammed death-ligand 1 (PD-L1) immunohistochemistry is a predictive biomarker for anti-PD-(L)1 therapy in non-small cell lung cancer (NSCLC). It is not a reliable predictor of clinical benefit with non-invasive imaging providing a potential solution. We present the PECan study, the aim of which to assess the relationship of [

methodsPD-L1 tumour proportion score (TPS) measured using SP263 assay. [

resultsFifteen patients were included (median age 63 years, 9 male). Intertumoural heterogeneity evident in 10(67%) patients. Mean [

conclusion[ CLINICAL TRIALS REGISTRATION: PD-L1 Expression in Cancer (PECan) study (NCT04436406), registered 18 June 2020 https://clinicaltrials.gov/ct2/show/NCT04436406.

Indexed as

Antibodies, Monoclonal, HumanizedB7-H1 AntigenCarcinoma, Non-Small-Cell LungLung NeoplasmsSingle Photon Emission Computed Tomography Computed TomographyAdultAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAntibodies, Monoclonal, HumanizedB7-H1 AntigenCD274 protein, humanFluorodeoxyglucose F18pembrolizumabRadiopharmaceuticals

Identifiers

PMID40188291
PMCPMC12081918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.