ArticleBMC nutrition2025
Association of low vitamin C concentrations and low consumption of fresh fruit and vegetables with cardiovascular disease in type 2 diabetes.
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Differential Effects of Vitamin C from Fruit and Vegetables Versus Supplements on the Risk of Frailty.Nutrients · 2025Article
- Pathophysiological Role and Therapeutic Potential of Vitamin C in Metabolic Syndrome and Type 2 Diabetes Mellitus.Metabolites · 2025Review
- Vitamin C in Cardiovascular Disease: From Molecular Mechanisms to Clinical Evidence and Therapeutic Applications.Antioxidants (Basel, Switzerland) · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVitamin C is a fundamental antioxidant with important metabolic actions in several biological processes. Patients with type 2 diabetes (T2D) are exposed to oxidative stress as a consequence of an increased production of reactive oxygen species (ROS). The aims of the present study were to estimate the prevalence of vitamin C deficiency in ambulatory patients with T2D, to study the relationship between vitamin C levels and cardiovascular diseases and to correlate the consumption of fresh fruit and vegetables with vitamin C levels and the presence of cardiovascular diseases.
methodsVitamin C levels, determined by high-performance liquid chromatography (HPLC), and consumption of fresh fruit and vegetables, assessed by a food frequency questionnaire, were measured in 200 outpatients with T2D. All other laboratory variables were measured by standard methods. The association between vitamin C and cardiovascular diseases was assessed by multivariable logistic regression analysis.
resultsVitamin C deficiency was found in 12.2% of the subjects. Vitamin C levels and consumption of fresh fruit and vegetables were lower in subjects with cardiovascular diseases. Consumption of fresh fruit and vegetables was associated with higher levels of vitamin C. In the multivariable analysis, vitamin C was independently associated with cardiovascular diseases.
conclusionIn conclusion, our study suggests that vitamin C may have an inverse relationship with cardiovascular diseases. Intake of vitamin C from fresh fruit and vegetables could play a protective role.
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