Evidence map›Paper›PMID 40188986›Full record

ArticleThe ocular surface2025

Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function.

Mehak Vohra, Simran Kumar, Peri Sohnen, Satinder Kaur, Sudha Swamynathan, Tomonori Hirose, Zbynek Kozmik, Shivalingappa K Swamynathan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ocular surface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mehak VohraDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA.
Simran KumarDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA.
Peri SohnenDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA.
Satinder KaurDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA.
Sudha SwamynathanDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA.
Tomonori HiroseDepartment of Molecular Biology, Yokohama City University, Yokohama, Japan.
Zbynek KozmikInstitute of Molecular Genetics of the ASCR, Prague, Czech Republic.
Shivalingappa K SwamynathanDepartment of Ophthalmology, University of South Florida, Tampa, FL, USA. Electronic address: SS65@USF.edu.

Funding

Ocular Surface Functions of KLF4 and KLF5R01EY026533 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI SWAMYNATHAN, SHIVALINGAPPA KOTTUR · 2016 to 2025
$3.4M
NEI NIH HHS R01 EY026533
6 · The paper itself

Abstract

purposeTo document the expression of apical-basal polarity (ABP) determinants in the mouse corneal epithelium (CE) and elucidate the functions of Pard3 in establishment and maintenance of ABP, stratification, homeostasis, and barrier function in the CE.

methodsPard3

resultsDynamic changes were observed in the expression and localization of ABP determinants as the CE stratified and matured between post-natal day 5 (PN5) and PN52. Adult Pard3

conclusionsDisruption of ABP in Pard3

Indexed as

Adaptor Proteins, Signal TransducingCell PolarityCytoskeletonEpithelium, CornealTight JunctionsAnimalsHomeostasisMiceMicroscopy, Electron, ScanningAdaptor Proteins, Signal TransducingApical-basal polarityBarrier functionCorneal epitheliumPar3Par6Pard3StratificationTight junction

Identifiers

PMID40188986
PMCPMC13455037

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.