Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011-2016.

Qiong Huang, Wenbin Nan, Siqi Li, Baimei He, Xu Cai, Zhenyu Peng, Chenlu Wu

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hyperuricemia and Hypoxic Pulmonary Hypertension: Pathogenic Links, Clinical Evidence, and Emerging Therapeutic Insights.Cardiovascular drugs and therapy · 2026
Review

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Qiong HuangDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Wenbin NanDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Siqi LiDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.

Baimei HeDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.

Xu CaiDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Zhenyu Peng *Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China. pengzhenyu1999@csu.edu.cn.

Chenlu Wu *Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, 410011, China. 228212236@csu.edu.cn.

Funding

Changsha Natural Science Foundation kq2007055Degree & Undergraduate Education Reform Project of Central South University 2022JGB076Hunan Provincial Natural Science Foundation 2022JJ30832Hunan Provincial Natural Science Foundation 2022JJ30853National Natural Science Foundation of China 81100221Research Fund Project of Hunan Provincial Health Commission B2014-023

6 · The paper itself

Abstract

Organophosphate esters (OPEs) exposure has potentially harmful effects on human health. However, the evidence between OPEs and hyperuricemia is insufficient. We aimed to assess the association between OPEs metabolites and the prevalence of hyperuricemia. Multivariable logistic regression, weighted quantile regression (WQS) model, and Bayesian kernel machine regression (BKMR) models were used to investigate the association of OPEs metabolites with the risk of hyperuricemia. Mediation analysis was conducted to assess whether inflammation mediated the effects of OPEs on the prevalence of hyperuricemia. The multivariable logistics regression indicated that bis (1,3-dichloro-2-propyl) phosphate (BDCPP) and bis-2-chloroethyl phosphate (BCEP) were positively correlated with the risk of hyperuricemia. In WQS and BKMR analyses, OPEs mixtures presented a positive association with the risk of hyperuricemia, with BDCPP being the primary contributor. C-reactive protein (CRP) and monocytes were found to mediate the association between BDCPP and the risk of hyperuricemia prevalence, with 8.46% and 3.97% of the mediated proportion, respectively. Our study revealed that OPEs mixtures were positively correlated with the prevalence of hyperuricemia, with BDCPP identified as the most significant contributor. Inflammation was a potential mechanism mediating the effect of BDCPP exposure on the risk of hyperuricemia.

Indexed as

Environmental ExposureEstersHyperuricemiaOrganophosphatesAdultBayes TheoremC-Reactive ProteinFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceUnited StatesC-Reactive ProteinEstersOrganophosphatesHyperuricemiaInflammationNHANESOPEsOrganophosphate esters

Identifiers

PMID40189692

DOI10.1038/s41598-025-96423-7

PMCPMC11973183

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.