Evidence map›Paper›PMID 40189730›Full record

ArticleMolecular neurobiology2025

Alleviated Neuroinflammation and Increased Neuritogenesis by Palmitic Acid from Cissus quadrangularis.

Mallikarjuna Nimgampalle, Anoop Ramachandra Bhat, Muthuraja Perumal, Pothapragada S K Prabhakar Ganesh, Gopinath Purushothaman, Vasudharani Devanathan

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Pink lotus flower (Biomedical reports · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mallikarjuna Nimgampalle *Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India. mallikarjuna@labs.iisertirupati.ac.in.
Anoop Ramachandra Bhat *Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India.
Muthuraja PerumalDepartment of Chemistry, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India.
Pothapragada S K Prabhakar GaneshDepartment of Chemistry, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India.
Gopinath PurushothamanDepartment of Chemistry, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India.
Vasudharani DevanathanDepartment of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Srinivasapuram, Venkatagiri Road, Jangalapalli Village, Panguru (G.P), Yerpedu Mandal, Tirupati, 517619, Andhra Pradesh, India. vasudharani@iisertirupati.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation and altered neurite outgrowth are pivotal pathological characteristic features of neurodegenerative disorders. Our research aims to explore the potential anti-neuroinflammatory activity of palmitic acid derived from Cissus quadrangularis. Our results reveal that palmitic acid at low concentrations significantly attenuates neuroinflammation in Neuro-2a cells by suppressing the expression of TNF-α and RhoA GTPase. Palmitic acid also modulates the activity of the small GTPase RhoA, a crucial regulator of cytoskeletal dynamics, thereby facilitating cytoskeletal rearrangements essential for neurite outgrowth. Our study also identifies those low concentrations of palmitic acid have a positive regulatory influence on cellular prion protein (PrP

Indexed as

InflammationNeuritesNeurogenesisNeuroinflammatory DiseasesPalmitic AcidAnimalsCell Adhesion Molecules, NeuronalCell LineExtracellular Matrix ProteinsLipopolysaccharidesMiceNerve Tissue ProteinsReelin ProteinrhoA GTP-Binding ProteinTumor Necrosis Factor-alphaCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsLipopolysaccharidesNerve Tissue ProteinsPalmitic AcidReelin ProteinReln protein, mouserhoA GTP-Binding ProteinTumor Necrosis Factor-alphaCellular prion protein PrPC and reelinLipopolysaccharideNeurite outgrowthNeuroinflammationPalmitic acidRho small GTPasesTNF-α

Identifiers

PMID40189730

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.