Evidence mapPaperPMID 40189749Full record

ArticleOncoimmunology2025

Surrogate markers of intestinal dysfunction associated with survival in advanced cancers.

Roxanne Birebent, Damien Drubay, Carolina Alves Costa Silva, Federica Marmorino, Giacomo Vitali, Gianmarco Piccinno, Yoan Hurtado, Adele Bonato, Lorenzo Belluomini, Meriem Messaoudene and 21 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Roxanne BirebentGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Damien DrubayGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Carolina Alves Costa SilvaGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Federica MarmorinoUnit of Medical Oncology 2, University Hospital of Pisa, Pisa, Italy.
Giacomo VitaliGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Gianmarco PiccinnoDepartment CIBIO, University of Trento, Trento, Italy.
Yoan HurtadoGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Adele BonatoGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Lorenzo BelluominiGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Meriem MessaoudeneCentre Hospitalier de l'Université de Montréal (CHUM), Hematology-Oncology Division, Department of Medicine, Montréal, QC, Canada.
Bertrand RoutyCentre Hospitalier de l'Université de Montréal (CHUM), Hematology-Oncology Division, Department of Medicine, Montréal, QC, Canada.
Marine FidelleGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Gerard ZalcmanThoracic Oncology Department-CIC1425/CLIP2 Paris-Nord, Bichat-Claude Bernard Hospital, AP-HP, Université Paris Cité, Paris, France.
Julien MazieresService de Pneumologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Clarisse Audigier-ValettePneumology Department, Centre Hospitalier Toulon Sainte-Musse, Toulon, France.
Denis Moro-SibilotDepartment of Thoracic Oncology, Centre Hospitalier Universitaire, Grenoble, France.
François GoldwasserINSERM U1016-CNRS UMR8104-Cochin Institute, Université Paris-Cité, Paris,France.
Arnaud ScherpereelDepartment of Pulmonary and Thoracic Oncology, University of Lille, University Hospital (CHU), INSERM unit OncoThAI, Lille, France.
Hervé PegliascoPulmonary Department, European Hospital, Marseille, France.
François GhiringhelliCancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.
Anna ReniGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Fabrice BarlesiGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Laurence AlbigesGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
David PlanchardGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Stéphanie MartinezService des Maladies Respiratoires, Centre Hospitalier d'Aix-en-Provence, Aix-en-Provence, France.
Benjamin BesseGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Nicola SegataDepartment CIBIO, University of Trento, Trento, Italy.
Chiara CremoliniUnit of Medical Oncology 2, University Hospital of Pisa, Pisa, Italy.
Laurence ZitvogelGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Valerio IebbaGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.
Lisa DerosaGustave Roussy Cancer Campus, ClinicObiome, Villejuif, France.ORCID 0000-0003-0527-2964

Funding

NCI NIH HHS U01 CA230551
6 · The paper itself

Abstract

Deviations in the diversity and composition of the gut microbiota are called "gut dysbiosis". They have been linked to various chronic diseases including cancers and resistance to immunotherapy. Stool shotgun based-metagenomics informs on the ecological composition of the gut microbiota and the prevalence of homeostatic bacteria such as

Indexed as

Carcinoma, Non-Small-Cell LungColorectal NeoplasmsDysbiosisGastrointestinal MicrobiomeLung NeoplasmsUrogenital NeoplasmsAgedAkkermansiaFemaleHumansMaleMiddle AgedPrognosisAkkermansiabiomarkerchemotherapycolorectal cancergenitourinary cancersGut dysbiosisimmune checkpoint inhibitorslung cancerMAdCAM-1

Identifiers

PMID40189749
PMCPMC11980478

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.