Evidence map›Paper›PMID 40189830›Full record

ArticleInternational journal of stem cells2025

Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids.

Sripriya Rajkumar, Ji-Hye Jung, Ji-Young Kim, Janardhan Keshav Karapurkar, Girish Birappa, D A Ayush Gowda, C Bindu Ajaykumar, Haribalan Perumalsamy, Bharathi Suresh, Kye-Seong Kim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sripriya RajkumarGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0006-4336-130X
Ji-Hye JungDepartment of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-1638-8823
Ji-Young KimDepartment of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-0112-2603
Janardhan Keshav KarapurkarGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-0198-4035
Girish BirappaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0000-7145-3638
D A Ayush GowdaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0001-7819-5456
C Bindu AjaykumarGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0001-2937-1046
Haribalan PerumalsamyResearch Institute for Convergence of Basic Science, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-6497-5857
Bharathi SureshGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0005-3277-9455
Kye-Seong KimGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0001-5550-1660
Seok-Ho HongDepartment of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-3372-442X
Suresh RamakrishnaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4038-1085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of chronic and lethal interstitial lung disease, termed idiopathic pulmonary fibrosis (IPF), remains unidentified. IPF induces pathological lung scarring that results in rigidity and impairs gas exchange, eventually resulting in premature mortality. Recent findings indicate that deubiquitinating enzymes play a key role in stabilizing fibrotic proteins and contribute to pulmonary fibrosis. The ubiquitin-specific protease 11 (USP11) promotes pro-fibrotic proteins, and its expression elevated in tissue samples from patients with IPF. Thus, this study aimed to examine the effects of loss of function of

Indexed as

Alveolar organoidDeubiquitinating enzymesLoss of functionPulmonary fibrosisUSP11

Identifiers

PMID40189830
PMCPMC12122244

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.