ArticleAmerican journal of human biology : the official journal of the Human Biology Council2025
In Search of Environmental Factors Associated With Global Differences in Birth Weight and BMI.
Article in American journal of human biology : the official journal of the Human Biology Council, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe "fetal origin of adult diseases hypothesis" encompasses the notion that intrauterine growth restriction (IUGR) alters fetal development trajectories. Various neonatal metrics inform IUGR, but not all contributors to IUGR have an impact on development trajectories. Chronic IUGR (twins) and slowly varying IUGR (seasonal) have little to no effect on later life trajectories. Perhaps development trajectories may evolve through other mechanisms, as for example, multiple short-lived periods of IUGR and repeated stimulation of metabolic pathways.
methodsDaily temperature variation could deliver a frequent IUGR as pregnant women would experience some degree of placental vasoconstriction during maximum/midday temperatures. We assessed the association with daily temperature amplitudes for globally distributed records of crude fetal growth rates (CFGR) and BMI. Paired birthweight (BW) and gestational age (GA) data permitted analyses of CFGR in 70 countries and subsequent analysis of CFGR for association with daily temperature amplitude, seasonal temperature amplitude, mean annual temperature, calorie intake per day per
resultsCFGR and BMI showed a clear association with daily temperature amplitudes, which was not the case for gestational age, calorie intake, and height.
conclusionWe show that daily temperature amplitudes are associated with both CFGR and BMI. These results permit a wider ecological appreciation of the hypothesis because daily temperature amplitudes inform environmental aridity and food scarcity. We discuss how scarcity, affluence, and the epidemiological environment influence the prevalence of afflictions associated with the fetal origin of adult disease hypothesis.
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